FORMULATION AND STATISTICAL OPTIMIZATION OF BILAYER SUBLINGUAL TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE

Priyanka Choudhury; Pulak Deb; Suvakanta Dash

doi:10.22159/ajpcr.2016.v9i5.13343

Authors

Priyanka Choudhury Girijananda Chowdhury Institute of Pharmaceutical Science(GIPS),Azara,Guwahati-17
Pulak Deb
Suvakanta Dash

DOI:

https://doi.org/10.22159/ajpcr.2016.v9i5.13343

Abstract

Objective: The aim of the present study is to formulate and optimize bilayer sublingual tablets of Levocetrizine hydrochloride and Ambroxol
hydrochloride using a 23 response surface methodology employing design expert-10.0. Sodium starch glycolate and Camphor were selected as
independent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses.
Methods: The bilayer sublingual tablets were prepared by direct compression and evaluated for various evaluation parameters including hardness,
thickness, friability, drug content uniformity, wetting time, water absorption ratio and disintegration time. The prepared optimized bilayer sublingual
tablets of Levocetrizine hydrochloride and Ambroxol hydrochloride having above 2 responses-disintegration time (sec) and water absorption ratio.
Results: The optimized batch having concentration of sodium starch glycolate and camphor was found within the standard limit of parametersdisintegration
time (sec) and water absorption ratio (%) as 61 sec and 69.67%.
Conclusion: The direct compression method in this study is relatively simple and safe and a stable, effective and pleasant tasting bilayer sublingual
tablet, which has a good balance over disintegration time and water absorption ratio, was formulated.
Keywords: Levocetirizine hydrochloride, Ambroxol hydrochloride, Croscarmellose sodium, Sodium starch glycolate, Camphor, Statistical optimization.

Downloads

Download data is not yet available.

Author Biography

Priyanka Choudhury, Girijananda Chowdhury Institute of Pharmaceutical Science(GIPS),Azara,Guwahati-17

M.Pharm in Pharmaceutics

References

Vishwakarma AG, Mogal RT, Pawar AY. Bi-layer tablet - A new ways in oral drug delivery system. Int J PharmTech Res 2014;6(5):1416-28.

Gandhi GS, Mundhada DR, Bhaskaran S. Levocetrizine orodispersible tablet by direct compression method. J Appl Pharm Sci 2011;01(05):145-50.

Ramana G, Sravanthi O, Sahithi G, Sindhu NV. Formulation and evaluation of controlled release hydrophilic matrices of ambroxol hydrochloride by melt granulation technique. AEJR 2012;7(4):150-9.

Sahoo BK, Mishra AK, Pal TK. Optimization and validation of modulated release formulation of ranitidine hydrochloride by response surface methodology. IJPSDR 2011;3(1):13-8.

Dekivadia M, Gudigennavar M, Patil C, Umarji B. Development & optimization of fast dissolving tablet of levocetrizine hydrochloride. Int J Drug Dev Res 2012;4(2):237-46.

Rane DR, Gulve HN, Patil VV, Thakare VM, Patil VR. Formulation and evaluation of fast dissolving tablet of albendazole. Int Curr Pharm J 2012;1(10):311-6.

Arunprashad B, Teja GK. Design and evaluation of bilayer tablets to treat respiratory tract infection. Int J Pharm Pharm Sci 2013;5(1):250-5.

Anjankumar PB, Nazmuddin M, Kulkarni U, Hariprasanna RC. Formulation and evaluation of lornoxicam fast dissolving tablet. Int Res J Pharm 2011;2(4):130-40.

Mohire NC, Yadav AV. Novel approach to formulate ÃŸ-cyclodextrin complexed mouth dissolving tablet of metronidazole and its in-vitro evaluation. J Pharm Res 2010;3(3):662-700.

Mishra RA. Optimization and characterization of rapidly dissolving films of cetirizine hydrochloride using cyclodextrins for taste masking. IJPRIF 2013;5(2):536-52.