EFFECT OF NATURAL AND SYNTHETIC POLYMERS ON THE PROPERTIES OF CANDESARTAN CILEXETIL MATRIX TABLET PREPARED BY DRY GRANULATION

Omar S Salih; Roaa A Nief

doi:10.22159/ajpcr.2016.v9s3.14719

Authors

Omar S Salih Baghdad university/college of pharmacy
Roaa A Nief university of Baghdad/college of pharmacy

DOI:

https://doi.org/10.22159/ajpcr.2016.v9s3.14719

Abstract

ABSTRACT
Objective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,
enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.
Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,
hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,
32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet.
Results: In vitro release showed that formula 13 had the faster release (100% after 4 h) which contained acacia (1:1) and the lowest sustain release
was showed for F7 (73% after 8 h) which contained HPMC K100M (1:1). Formula 1 was an 89 % release after 8 h which contain eudragit RS100; F4
was a 100 % release after 5 h which contain Na CMC, F10 was a 100% after 8 h which contain xanthan gum and F16 was a 100 % release after 5 h
which contain tragacanth polymer. Formula 9 had a lower release than F7 and F8 respectively. Formula 7 can be used for sustain oral drug delivery of
candesartan cilexetil while Formula 13 can be used in contrary as fast release tablets for faster response.
Conclusion: Controlled drug delivery system is promising for less dosing and higher patient compliance.
Keywords: Angiotensin II receptor antagonist, Hypertension, Matrix system, Control release.

Downloads

Download data is not yet available.

Author Biography

Omar S Salih, Baghdad university/college of pharmacy

department of pharmaceutics

References

Vishnu P, Naveen KB, Sunitha MR. Formulation and evaluation of candesartan cilexetil floating tablets by melt granulation technique. IJRPC 2015;5(2):373-9.

Al-Nuss R, El-Zein H. Enhancement of candesartan cilexetil dissolution rate by using different methods. Asian J Pharm Clin Res 2015;8(1): 320-6.

Dhrupesh P, Upendra P, Bhavin B, Dhiren D, Ghanshyam P. Formulation and evaluation of sustained release matrix tablets of candesartan cilexetil. IJPRBS, 2012;1(4): 75-101.

Bandyopadhyay S, Lohit B, Devi L. An explicit review on quantitative estimation of candesartan cilexetil employing various analytical techniques. Pharm Anal Acta 4:254. DOI: 10.4172/2153-2435.

Darphade SM, Shejul AA, Tathe PR, Biyani KR. Formulation and characterization of sustained release matrix tablet of metoprolol succinate by using combination of natural and synthetic polymer. Int J Res Pharm Biomed Sci 2013;4(3):901-6.

Sasidhar RL, Vidyadhara, S, Krishna NR, Nagaraju R. Design and evaluation of losartan potassium matrix tablets with natural and synthetic polymers. Int J Pharm Sci Res 2012;3(3):928.

Chandramouli Y, Firoz S, Vikam A, Padmaja C, Chakravarthi VN. Design and evaluation of controlled release matrix tablets of acyclovir sodium using tamarind seed polysaccharides. J Pharm Biol 2012;2(2):55-62.

Shanmugam S, Baskaran R, Balakrishnan P, Thapa P, Yong CS, Yoo BK. Granulation techniques and technologies: Recent progresses. Bio Impacts 2015;5(1):55.

Kondeti RR, Mulpuri KS, Koganti M, Rathnam G. A comparative study on different methods of granulation on tablet properties. Asian J Pharm Technol Innov 2014, 2(7).

Basak SC, Kesevan SK, Murugesan R. Design and release characteristics of sustained release tablet containing metformin HCl. Rev Bras CiÃªn Farm 2008;44(3):477-83.

Bhowmik A, Nijhu RS, Ahmed T, Sultana S. Design and development of atenolol matrix tablet employing natural and synthetic polymers. J Appl Pharm Sci 2013;3(9):13.

Girish B, Ismail P, Gowda D. Formulation and evaluation of sustained release matrix tablets of flurbiprofen using guar gum. Int J Pharm Pharm Sci 2012;4:120-3.

Abbas AA, Rasool A, Nawal AR. Preparation and comparative evaluation of liquisolid compact and solid dispersion of candesartan cilexetil. Int J Pharm Pharm Sci 2014;6 Suppl 2:257-66.

Salih OS. Study the sustain release effect of different polymers used in the formulation of aspirin-rosuvastatin tablets. Int J Pharm Pharm Sci 2015;7(12):166-72.

Ofori-Kwakye K, Mfoafo KA, Kipo SL, Kuntworbe N, El-Boakye-Gyasi M. Development and evaluation of natural gum-based extended release matrix tablets of two model drugs of different water solubilities by direct compression. Saudi Pharm J 2016;24(1):82-91.

Arora G, Malik K, Singh I, Arora S, Rana V. Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum. J Adv Pharm Technol Res 2011;2(3):163-9.

Shah RB, Mobin AT, Mansoor AK. Comparative evaluation of flow for pharmaceutical powders and granules. AAPS PharmSciTech 2008;9(1):250-8.

Aulton, M. E. Pharmaceutics: The Science of Dosage form Design. 1st ed. London: Churchill Livingstone; 1998.

Talukdar. MM, Kinget R. Comparative study on xanthan gum and hydroxypropylmethyl cellulose as matrices for controlled-release drug delivery. II. Drug diffusion in hydrated matrices. Int J Pharm 1997;151:99-107.

Ghafourian T, Bozorgi AH. Estimation of drug solubility in water, PEG 400 and their binary mixtures using the molecular structures of solutes. Eur J Pharm Sci 2010;40(5):430-40.

Revathi T, Ethiraj Z, Jhansi L, Marreddy S, Ganeshan V. Development and validation of a dissolution test for candesartan cilexetil in tablet forms using reverse phase - High performance liquid chromatography. J Pharm Educ Res 2011;2:22-36.

Shukla JB, Patel SJ. Formulation and evaluation of self-microemulsifying system of candesartan cilexetin. Int J Pharm Pharm Sci 2010;2(4):143-6.

Sinko PJ, Alfred NM. Physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Martinâ€™s Physical Pharmacy and Pharmaceutical Sciences. Solubility and Distribution Phenomena. 6th ed. Lippincott: Williams & Wilkins; 2011. p. 184.

Albhar KG, Vaibhav SW, Chavan BB. Effect of HPMC K4M, HPMC K15M, sodium alginate and carbopol 934 in the formulation of carbonyl iron capsule. J Der Pharm Lett 2012;4(1):94-367.

Roy H, Chandan KB, Sisir N, Kirti RP. Formulation and design of sustained release matrix tablets of metformin hydrochloride: Influence of hypromellose and polyacrylate polymers. Int J Appl Basic Med Res 2013;3(1):55.

Kaushik AY, Ajay KT, Ajay G. Role of excipients and polymeric advancements in preparation of floating drug delivery systems. Int J Pharm Invest 2015;5(1):1-12.

Palmer D, Levina M, Nokhodchi A, Douroumis D, Farrell T, Rajabi-Siahboomi A. The influence of sodium carboxymethylcellulose on drug release from polyethylene oxide extended release matrices. AAPS PharmSciTech 2011;12(3):862-71.

Kaffashi B, Zandieh A, Khadiv-Parsi P. Drug release study of systems containing the tragacanth and collagen composite: Release characterization and viscoelastic measurements. Macromol symp 2006;76(1):230-239.

Reddy PU, Reddy BV, Navaneetha K. Formulation and evaluation of candesartan immediate release tablets by using liquisolid. World J Pharm Pharm Sci 2013;3(2):2270-82.

Zhang Y, Huo M, Zhou J, Zou A, Li W, Yao C, et al. DDSolver: An add-in program for modeling and comparison of drug dissolution profiles. AAPS J 2010;12:263-71.

Naseera K, Sajeeth CI, Santhi K. Formulation, optimization and evaluation of matrix type of transdermal system of simvastatin using permeation enhancers. Int J Curr Pharm Res 2012;4(2):79-87.