INHALATION THERAPY - APPROACHES AND CHALLENGES

Authors

  • Sayani Bhattacharyya Department of Pharmaceutics, Krupanidhi College of Pharmacy, No: 12/1 Carmelaram Road, Chikka Bellandur, Varthur, Hobli, Carmelaram Post, Bengaluru – 560 035, Karnataka, India.
  • Bharani S Sogali Department of Pharmaceutics, Krupanidhi College of Pharmacy, No: 12/1 Carmelaram Road, Chikka Bellandur, Varthur, Hobli, Carmelaram Post, Bengaluru – 560 035, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i4.24117

Keywords:

Lung, Inhalation, Target, Local delivery, Systemic delivery, Novel technologies

Abstract

 Inhalation therapy is an effective way for local and systemic delivery of miscellaneous drugs for pulmonary and non-pulmonary diseases. The inhalation therapy aims to target specific cells or regions of the lung, bypassing the lung's clearance mechanisms and thereby providing high retention of the drug for longer periods. It helps in improved penetration of intravenously administered antibiotics into lung parenchymal tissue and bronchial secretions, and as a result, their potential systemic toxicity is reduced when given over prolonged periods of time. The advancement in device technology supports the development of more efficient therapy in the form of delivering finer particles into the lung in large doses. Therefore, meticulous daily management of lung disease, together with prompt, aggressive treatment of exacerbations can be achieved through inhalation to preserve lung function. This review summarizes the features of inhalation delivery devices, their advantages and limitations, challenges in formulation and brief description of novel technologies currently marketed.

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Published

01-04-2018

How to Cite

Bhattacharyya, S., and B. S Sogali. “INHALATION THERAPY - APPROACHES AND CHALLENGES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 4, Apr. 2018, pp. 9-16, doi:10.22159/ajpcr.2018.v11i4.24117.

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Section

Review Article(s)