DESIGN AND COMPARATIVE EVALUATION OF CLARITHROMYCIN GASTRIC BIOADHESIVE TABLETS BY EX VIVO AND IN VIVO METHODS
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i4.24325Keywords:
Tamarind seed polysaccharide, Mucoadhesive tablets, Clarithromycin, X-ray, High-performance liquid chromatography-mass spectrometry, ex vivo methodsAbstract
 Objective: The present investigation was to formulate controlled release of mucoadhesive clarithromycin tablets using natural polymers.
Methods: Tamarind seed polysaccharide obtained from Tamarindus indica and chitosan act as natural polymers. The formulated tablets of the combined form of thrombospondin (TSP) and chitosan were analyzed by in vitro dissolution method. The optimized formulations were selected for ex vivo and in vivo studies and compared with hydroxypropyl methylcellulose K100 polymer by evaluating gastric retention period by X-ray imaging technique, and drug bioavailability by a pharmacokinetic method from blood samples was determined by high-performance liquid chromatography-mass spectrometry method.
Results: The gastric mucoadhesive tablets were prepared using chito-TSP polymers. The in vitro drug release showed good release character for 24 h. The ex vivo studies of tablets showed good adhesive property for a long time. The X-ray imaging technique also proved the adhesive character of tablets. From blood serum sample of rabbits, bioavailability of the drug is in according to the controlled release mechanism.
Conclusion: The selected formulations were subjected to stability studies. The study concluded that combination of chitosan and TSP is best natural polymer for mucoadhesion by the advantages of controlled release and biodegradation.
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Khan MS, Rohitash K, Vijaykumar M, Pandey SC, Vishakante GD, Ahmed FM, et al. Development and evaluation of nasal mucoadhesive nanoparticles of an analgesic drug. Sch Res Libr Pharm Lett 2012;4:1846-54.
Kumar A, Singh N. Formulation and in vitro evaluation of combined floating mucoadhesive tablet of clarithromycin by using natural polymers. Int J Res Pharm Biomed Sci 2014;5:214-6.
Tejaswi BS, Sivadasan D, Devi S. Formulation and in vitro evaluation of clarithromycin floating microspheres for eradication of helicobacter pylori. Sch Res Libr Pharm Lett 2011;3:90-101.
Pawar Y, lalwani DN, Derle DV. Formulation and development of gastroretentive optimized once a day floating and/or bioadhesive tablet of ofloxacin. Int J Drug Deliv 2012;4:326-35.
Khurana S, Satheesh madhav NV. Mucoadhesive drug delivery: Mechanism and methods of evaluation. Int J Pharm Biosci 2013;2:215-21.
Wadher KJ, Kakde RB, Umekar MJ. Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers. Indian J Pharm Sci 2011;73:208-15.
Singh S, Govind M, Bothara SB. A review on in vitro-in vivo mucoadhesive strength assessment. Pharma Tech Med 2013;1:221-7.
Bhanja S, Shafeeque MZ, Sudhakar M. Mucoadhesive buccal tablets of glimeperide- formulation and evaluation. Int J Pharm Pharm Sci 2013;5:111-4.
Sudarshan S, Sunil B. In vivo mucoadhesive strength appraisal of gum manilkara zapota. Braz J Pharm Sci 2015;51:689-98.
Mukherjeea A, Sahoob NS, Sarmac HD. Preparation and evaluation of three mucoadhesive dosage forms using 99mTC-Ofloxacin. Appl Radiat Isot 2014;89:192-8.
Oliveira PR, Mendes C, Klein I, Sangoi MS, Bernardi LS, Silva MA. Formulation development and stability studies of norfloxacin extended-release matrix tablets. Biomed Res Int 2013;2013:716-36.
Goswami DS, Sharma M. Development of new mucoadhesive polymer from natural source. Asian J Pharm Clin Res 2012;5:212-5.
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