COMPARATIVE STUDY OF BUTANOLIC AND ETHANOLIC EXTRACTS OF TRIBULUS TERRESTRIS FRUITS IN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED HEPATOTOXICITY IN RATS

RAJESWARI HARI; MURALIDHARAN P

doi:10.22159/ajpcr.2018.v11i6.24992

Authors

RAJESWARI HARI Department of Biotechnology, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.
MURALIDHARAN P Department of Pharmacology and Toxicology, C.L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.24992

Keywords:

Ethanolic extract of T terrestris, Hepatoprotective, Oxidative stress, Saponin rich fraction of T terrestris, 2, 3, 7, 8-Tetrachlorodibenzo-pdioxin

Abstract

Objective: To compare hepatoprotective activity of ethanol and butanol fraction of Tribulus terrestris fruits against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hepatic damage in albino rats.

Methods: The degree of liver protection was assessed in terms of biochemical parameters, liver marker enzymes, and lipid peroxidation (LPO) in drug-treated and TCDD-intoxicated rats.

Results: The results revealed that the elevated serum marker enzymes and biochemical parameters in TCDD-treated rats were significantly reduced toward normal levels in saponin rich fraction of T. terrestris drug-treated animals when comparable to ethanolic extract of T. terrestris drug-treated group. The plant extracts have got a notable inhibitory activity on the formation of LPO products in the basal as well as in the presence of inducers.

Conclusion: The plant extracts hindered oxidative damage that occurred to the hepatocytes during TCDD toxicity may be responsible for the hepatoprotective activity in the present study.

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Author Biography

RAJESWARI HARI, Department of Biotechnology, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.

Professor and Head

depaartment of Biotechology

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