A COMPARISON OF INTRAVENOUS ONDANSETRON AND PALONOSETRON IN PREVENTING POST-OPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY - A RANDOMIZED DOUBLE-BLIND STUDY

Ajay Kumar; Sumita Adhana; Puneet Dwivedi

doi:10.22159/ajpcr.2018.v11i12.27712

Authors

Ajay Kumar Department of Anaesthesiology and Critical Care, Deen Dayal Upadhyay Hospital, New Delhi, India. http://orcid.org/0000-0001-9703-3893
Sumita Adhana Department of Anaesthesiology and Critical Care, Deen Dayal Upadhyay Hospital, New Delhi, India.
Puneet Dwivedi Department of Anaesthesiology and Critical Care, Deen Dayal Upadhyay Hospital, New Delhi, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i12.27712

Keywords:

Palonosetron, Ondansetron, Post-operative nausea and vomiting, Laparoscopy, Cholecystectomy

Abstract

Objectives: Post-operative nausea and vomiting (PONV) is a frequently experienced complication following laparoscopic cholecystectomy. This study was planned to compare the antiemetic efficacy of palonosetron with ondansetron in patients undergoing laparoscopic cholecystectomy.

Methods: A total of 100 patients undergoing laparoscopic cholecystectomy were randomized into two groups. Group O (n=50) received ondansetron (8 mg) and Group P (n=50) received palonosetron (0.075 mg) 3 min before induction of anesthesia. Post-operatively, patients were assessed for the occurrence of nausea, retching, or vomiting at 0â€“2, 2â€“6, 6â€“24, 0â€“24, and 24â€“48 h time intervals. The overall incidence of PONV in time frame (0â€“48 h) was determined. The need of rescue antiemetic, side effect profile, and patient satisfaction scores were also assessed.

Results: The incidence and severity of nausea at all the time intervals were comparable in the two groups. The incidence of vomiting was significantly less in Group P as compared to Group O in 0â€“2 h (2% vs. 14%, p=0.027) and 0â€“24 h time intervals (10% vs. 30%, p=0.012). The overall incidence of PONV in 0â€“48h was lesser in Group P as compared to Group O (28% vs. 50%, p=0.024). Rescue antiemetic was required in greater number of patients in Group O as compared to Group P (p=0.038). Side effect profile and patient satisfaction scores were comparable in the two groups.

Conclusion: Palonosetron is better than ondansetron in lowering the overall incidence of PONV in 0â€“48 h time interval, in patients undergoing laparoscopic cholecystectomy.

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