EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA LINN. AND DIOSMETIN ON MODULATION OF SPATIAL MEMORY THROUGH ACETYLCHOLINESTERASE AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN ETHANOL-INDUCED COGNITIVE IMPAIRMENT MODEL RATS

Authors

  • Sasikumar A Department of Physiology, Tagore Medical College and Hospital, Rathinamangalam, Chennai, Tamil Nadu, Affiliated to The TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.
  • Suba Malani S Department of Physiology, Tagore Medical College and Hospital, Rathinamangalam, Chennai, Tamil Nadu, Affiliated to The TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.
  • Manikandan S Department of Physiology, Tagore Medical College and Hospital, Rathinamangalam, Chennai, Tamil Nadu, Affiliated to The TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.
  • Ramaswamy C Department of Physiology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Thandalam, Kancheepuram, Chennai, Tamil Nadu, India.
  • Senthilkumar S Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i12.27992

Keywords:

Glycyrrhiza glabra Linn, Diosmetin, Ethanol, Cognitive impairment, Spatial memory

Abstract

Objective: The objective of this research was to evaluate the cognitive impairment due to excessive consumption of alcohol and memory enhancement action of Glycyrrhiza glabra Linn. (AEGGL) and diosmetin (Dm).

Methods: In this study, 36 adult male Wistar rats were divided into the six groups (n=6) and eight-arm radial maze, narrow beam test, and open field behavior parameters were assessed on day 1, 10, and 21. After the 21 days of experiment, animals were sacrificed, and blood samples were collected for serum acetylcholinesterase (AChE) and brain-derived neurotrophic factor (BDNF) estimation. We have also analyzed the morphology of CA3 region of the hippocampus.

Results: The results of this study suggested that AEGGL and Dm treatment could be the potential drugs for ethanol-induced cognitive impairment.

Conclusion: Ethanol-induced cognitive impairment was recovered by AEGGL and Dm treatment, we suggested that this might be due to anticholinesterase activity and increased synthesis of BDNF levels in the brain. Further, researches are warranted to understand the exact mechanism of action of drugs.

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Author Biographies

Sasikumar A, Department of Physiology, Tagore Medical College and Hospital, Rathinamangalam, Chennai, Tamil Nadu, Affiliated to The TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.

Physiology

Manikandan S, Department of Physiology, Tagore Medical College and Hospital, Rathinamangalam, Chennai, Tamil Nadu, Affiliated to The TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.

Physiology

Ramaswamy C, Department of Physiology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Thandalam, Kancheepuram, Chennai, Tamil Nadu, India.

Physiology

Published

07-12-2018

How to Cite

A, S., S. M. S, M. S, R. C, and S. S. “EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA LINN. AND DIOSMETIN ON MODULATION OF SPATIAL MEMORY THROUGH ACETYLCHOLINESTERASE AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN ETHANOL-INDUCED COGNITIVE IMPAIRMENT MODEL RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 12, Dec. 2018, pp. 437-43, doi:10.22159/ajpcr.2018.v11i12.27992.

Issue

Vol 11 Issue 12 December 2018

Section

Original Article(s)

The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.

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