ANTI-OBESITY EFFECT OF CANNABIS SATIVA SEED FLOUR FROM KHLALFA OF TAOUNATE REGION (NORTHERN OF MOROCCO) IN HIGH CALORIC DIET-INDUCED OBESE MICE

MOUNA BOUARFA; ZOUHAIR SOUIRTI; PIERFRANCESCO CERRUTI; MAURIZIO AVELLA; ABDELLAH FARAH; DALILA BOUSTA

doi:10.22159/ajpcr.2020.v13i11.39304

Authors

MOUNA BOUARFA Laboratory of Neuroendocrinology and Nutritional and Climatic Environment. Faculty of Sciences, Sidi Mohamed Ben Abdellah University, B.P. 1796, Atlas, Fez, Morocco.
ZOUHAIR SOUIRTI CHU Hassan II - Neurology - 30000 - Fez – Morocco.
PIERFRANCESCO CERRUTI 3Institute for Polymers, Composites and Biomaterials (IPCB-CNR), Naples, Italy.
MAURIZIO AVELLA Institute for Chemistry and Technology of Polymers (ICTP-CNR), Naples, Italy.
ABDELLAH FARAH Laboratory of Applied Organic Chemistry, Faculty of Sciences and Technology, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
DALILA BOUSTA Laboratory of Neuroendocrinology and Nutritional and Climatic Environment. Faculty of Sciences, Sidi Mohamed Ben Abdellah University, B.P. 1796, Atlas, Fez, Morocco.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i11.39304

Keywords:

Cannabis sativa seed flour, Anti-obesity, Mice, Kidney, Liver, Taounate, Kif, Khlalfa

Abstract

Objective: The objective of the present study was to evaluate the anti-obesity activity of Cannabis sativa seed Flour (CSSF) on obese mice.

Methods: The experiment process was carried out in 8 weeks. In this time, three groups of animals were adopted: High caloric diet control group (HCD), group treated with 100 mg/kg of CSSF, group treated with 200 mg/kg of CSSF, and normal diet control group (ND). Then, the histopathological and biochemical parameters analysis has been realized at the end of the experiment.

Results: As a result, body weight gain, epididymal, and perirenal adipose tissue decreased in the CSSF (Cannabis sativa seed Flour) group in both doses (100 mg/kg and 200 mg/kg) compared to the HCD. CSSF lowered serum glucose level elevated by HCD. For lipid profiles, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and triglycerides (TG) significantly decreased in the CSSF group. The histopathological results of this study showed a regenerative effect of CSSF on the kidney and liver tissues.

Conclusion: It is concluded from the present study that CSSF can be used as a natural anti-obesity agent.

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