A PROSPECTIVE STUDY TO COMPARE COMBINED USE OF INTRAVAGINAL MISOPROSTOL AND INTRACERVICAL FOLEY CATHETER VERSUS INTRAVAGINAL MISOPROSTOL ALONE FOR TERMINATION OF MID-TRIMESTER PREGNANCY IN DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY SMS MEDICAL COLLEGE, JAIPUR

Authors

  • Monika Yadav Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur, Rajasthan, India.
  • Urmila mahala Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i7.47446

Keywords:

Misoprostol, Foley catheter, Mid-trimester pregnancy

Abstract

Objectives: The aims and objectives of the study are to compare the mean induction to abortion interval and efficacy of intra-vaginal misoprostol alone versus combined use of intravaginal misoprostol and intracervical Foley catheter in termination of mid-trimester pregnancy.

Methods: This was prospective, comparative study conducted during March 2021 to April 2022 at Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur. The study included sample size of 60 cases (30 cases in each group). 60 cases were randomly allocated to either intravaginal misoprostol alone (Group A) or combined use of intravaginal misoprostol and Foley catheter (Group B) for termination of mid-trimester pregnancy. The study included all pregnant females between 14 and 20 weeks of gestation who were admitted for termination of pregnancy.

Results: Mean induction to abortion interval±standard deviation for Group A was 20.79±2.01 h and for Group B, it was 17.29±3.58 h. Mean dose of tablet misoprostol required for Group A±standard deviation was 1453.3±267.47 mcg and for Group B, it was 1053.33±267.47 mcg.

Conclusion: In this study, we found that with the combined use of intravaginal misoprostol and intracervical Foley catheter, there was a significant reduction in duration of induction to abortion, total dose misoprostol required, and hospital stay than in intravagnial misoprostol alone in termination of mid-trimester pregnancy.

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References

Islam A, Abbasi AU, Sarwar I. Use of Foley’s catheter and prostaglandin F-2 alpha in second trimester termination of pregnancy. J Ayub Med Coll Abbottabad 2005;18:35-9.

Drey EA, Foster DG, Jackson RA, Lee SJ, Cardenas LH, Darney PD. Risk factors associated with presenting for abortion in the second trimester. Obstet Gynecol 2006;107:128-35.

Boyd PA, Tondi F, Hicks NR, Chamberlain PF. Autopsy after termination of pregnancy for fetal anomaly: Retrospective cohort study. BMJ 2004;328:137.

Ahmad S, Meraj B, Mobusher I. Comparison of misoprostol and PGF2 alpha for second trimester termination of pregnancy. Pak J Med Health Sci 2015;9:526.

Cunningham FG, Leneno KJ, Bloom SL, Sponge CY, Dashe JS, Hoffman BL, et al. Abortion. In: Williams Obstetrics. 24th ed., Ch. 18. p. 369. Available from: https://accessmedicine.mhmedical. com/content.aspx?bookid=1057&sectionid=59789157 [Last accessed on 2020 Mar 10].

Yapar EG, Senoz S, Urkutur M, Batioglu S, Gökmen O. Second trimester pregnancy termination including fetal death: Comparison of five different methods. Eur J Obstet Gynecol Reprod Biol 1996;69:97-102.

Pongsatha S, Tongsong T. Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol. J Obstet Gynaecol Res 2004;30:217-20.

Liaquat NF, Javed I, Shuja S, Shoaib T, Bano K, Waheed S, et al. Therapeutic termination of second trimester pregnancies with low dose misoprostol. J Coll Physicians Surg Pak 2006;16:464-7.

Hamoda H, Ashok PW, Flett GM, Templeton A. A randomized trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion at 13-20 weeks gestation. Hum Reprod 2005;20:2348-54.

Ashok PW, Templeton A, Wagaarachchi PT, Flett GM. Midtrimester medical termination of pregnancy: A review of 1002 consecutive cases. Contraception 2004;69:51-8.

Mahajan P, Sharma N, Sharma P. Study to compare the effectiveness of intravaginal misoprostol alone with combined use of intravaginal misoprostol and intracervical foley’s catheter for termination of mid trimester pregnancy. Int J Reprod Contracept Obstet Gynecol 2020;9:2560-5.

Kanta S, Sharma P, Sharma S, Sharma M. Comparison of intravaginal misoprostol alone and in combination with intracervical foley’s catheter for termination of second trimester pregnancy at a tertiary care hospital. Medpulse Int Med J 2018;5:100-2.

Published

07-07-2023

How to Cite

Yadav, M., and U. mahala. “A PROSPECTIVE STUDY TO COMPARE COMBINED USE OF INTRAVAGINAL MISOPROSTOL AND INTRACERVICAL FOLEY CATHETER VERSUS INTRAVAGINAL MISOPROSTOL ALONE FOR TERMINATION OF MID-TRIMESTER PREGNANCY IN DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY SMS MEDICAL COLLEGE, JAIPUR”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 7, July 2023, pp. 79-81, doi:10.22159/ajpcr.2023.v16i7.47446.

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