EVALUATION OF A NOVEL, NATURAL LOCUST BEAN GUM AS A SUSTAINED RELEASE AND MUCOADHESIVE COMPONENT OF TIZANIDINE HYDROCHLORIDE BUCCAL TABLETS
Abstract
Mucoadhesive polymers that bind to the gastric mucins or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy andduration of contact of the drug with the absorbing membrane. Mainly synthetic polymers are in use for this purpose. Probably the biodegradability of thesynthetic polymers is questionable. In the present work mucoadhesive buccal tablets of tizanidine hydrochloride were prepared using locust bean gumthat has better mucoadhesive property than synthetic polymer. The in vitro adhesive and mucoadhesive strength and swelling property of mucoadhesivmaterial locust bean gum were evaluated by Share Stress and Park and Robinson methods. Buccal formulations of tizanidine hydrochloride tablets werprepared using locust bean gum, and thickness, hardness, friability, weight variation, and assay of tablets were tested. The in vitro drug release studof tizanidine hydrochloride exhibited extended drug release profile for tablets prepared. Higuchi and Peppas data reveal that the drug released by nonFickian
diffusion mechanism. The present
study
shows
that formulation
containing 50% locust bean gum have
greater
mucoadhesive
property
than allother
formulation.
Increase
in concentration
of locust bean gum increases
in the bioadhesive
strength
and swelling
ratio
in the 50
mg
of locust bean gum.
Keywords: Mucoadhesive, Tizanidine hydrochloride, Tablets, Locust bean gum.
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