FORMULATION AND STABILITY INDICATING ANALYSIS OF ORODISPERSIBLE TABLET OF PIROXICAM
Abstract
The main object of this research work is to develop and studying the stability analysis of orodispersible tablet of piroxicam. Five formulations
of orodispersible tablets of piroxicam (F1-F4) were prepared using two different superdisintegrants namely crospovidone and sodium
starch glycolate with two concentrations and a control F5 (without superdisintegrant) by direct term stability studies for the formulations
showed no significant changes in disintegration compression method. The precompression and post compression study of piroxicam and
excipient were carried out. The short time, drug content and percentage of drug released when stored at 4°C±2°C, 27°C ±2°C, and 45°C±2°C
for 15 days.
Keywords: Orodispersible, Stability, Piroxicam, Anti-inflammatory, Direct compression, Superdisintegrant.
Downloads
References
Rajesh M, Kiran RN, Palanichamy S, Thirupathi T. Formulation
and evaluation of orodispersible piroxicam. J Pharm Sci Res
;2(10):615-21.
Chang RK, Guo X, Burnside B, Couch R. Fast-dissolving tablets.
Pharm Technol 2000;24:52-8.
Habib W, Khankari R, Hontz J. Fast-dissolving drug delivery system.
Crit Rev Ther Drug Carrier Syst 2000;17:61-72.
Schettler T, Paris S, Pellett M, Kidner S, Wilkinson D. Comparative
pharmacokinetics of two fast-dissolving oral ibuprofen formulations
and a regular release ibuprofen tablet in healthy volunteers. Clin Drug
Invest 2001;21:73-8.
Fini A, Bergamante V, Ceschel GC, Ronchi C, de Moraes CA. Fast
dispersible/slow releasing ibuprofen tablets. Eur J Pharm Biopharm
;69(1):335-41.
Liberman HA, Lachman L, Schawstr JB. Pharmaceutical Dosage
Forms: Tablets. Vol. 2. New York: M. Dekker; 1989. p. 173-7.
Aulton ME. Characteristic of disintegrants. Pharmaceutics. 2nd ed. ???:
???; 2001. p. 406-40.
Asian J Pharm Clin Res, Vol 8, Issue 6, 2015, 115-119
Pande and Rangari
Cean CS, Glashan JM, Neathercoat GC, Parsons AV. Martindale:
The Complete Drug Reference. 35
ed., Vol. 1. Great Britain: RPS
Publishers; 2007. p. 815-7.
th
Cooper J, Gunn C. Power flow and compaction: In: Caroter SJ, editor.
Tutorial Pharmacy. New Delhi, India: CBS Publishers and Distributors;
p. 211-33.
Subrahmanyam CV. Laboratory Manual of Physical Pharmaceutics.
ed. New Delhi, India: Vallabh Prakashan; 2002. p. 46-53.
The Official Compendia of Standards. United States Pharmacopoeia and
st
National Formulary. Vol. 546-7. Asian: United States Pharmacopeial
Convention, Incorporated; 2000. p. 2148-9.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.