ANTI-PYRETIC ACTION OF Caulerpa lentillifera, Hibiscus rosa-sinensis AND Piper sarmentosum AQUEOUS EXTRACT IN MICE
Abstract
Objective: The present study was conducted to evaluate the anti-pyretic activity of Caulerpa lentillifera, Hibiscus rosa-sinensis, and Piper sarmentosum
aqueous extracts.
Methods: The suspension of yeast was injected intraperitoneally (0.1 g/kg of bodyweight [BWT]) to induce fever in experimental animals. Rectal
temperature was recorded every hour with a lubricated digital thermometer and animals with at least 0.7°C elevations in body core temperature
were included in the experiment. The animals with fever were administered orally with aqueous extracts of C. lentillifera, H. rosa-sinensis, and
P. sarmentosum (500 mg/kg of BWT). Another group was given the commercial drug, acetaminophen (10 mg/kg of BWT), to serve as a control.
Results: The result of the study showed that C. lentillifera and H. rosa-sinensis aqueous extracts significantly (p<0.05) effective in combating fever.
However, P. sarmentosum aqueous extract has no potential as an anti-pyretic agent.
Conclusion: H. rosa-sinensis and C. lentillifera aqueous extracts have anti-pyretic potential but not P. sarmentosum aqueous extract.
Keywords: Caulerpa lentillifera, Hibiscus rosa-sinensis, Piper sarmentosum, Anti-pyretic, Fever, Pyrexia, Yeast.
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References
Axelrod YK, Diringer MN. Temperature management in acute
neurologic disorders. Neurol Clin 2008;26(2):585-603, xi.
Kumar A. Medicinal plants as a source of antipyretic agent in Terai
Region of Utter Pradesh, India. Life Sci Leafl 2012;2:45-52.
Chattopadhyay D, Arunachalam G, Ghosh L, Rajendran K, Mandal AB,
Bhattacharya SK. Antipyretic activity of Alstonia macrophylla Wall
ex A. DC: An ethnomedicine of Andaman Islands. J Pharm Pharm Sci
;8(3):558-64.
Begum TN, Ilyas MH, Anand AV. Antipyretic activity of Azima
tetracantha in experimental animals. Int J Curr Biomed Pharm Res
;1(2):41-4.
Gege-Adebayo GI, Bassi AS, Igbokwe VU, Shafe MO. Antipyretic
effect of Ocimum gratissium on brewer’s yeast induced fever in wistar
rats. J Med Med Sci 2013;4(6):247-51.
Thenmozhi M, Dhanalakshmi M, Manjula-Devi K, Sushila K,
Thenmozhi S. Evaluation of hepatoprotective activity of Leucas aspera
hydroalcoholic leaf extract during exposure to lead acetate in male
albino wistar rats. Asian J Pharm Clini Res 2013;6(1):78-81.
Nguyen VT, Ueng JP, Tsai GJ. Proximate composition, total phenolic
content, and antioxidant activity of seagrape (Caulerpa lentillifera).
J Food Sci 2011;76:C950-8.
Mohamed S, Hashim SN, Rahman HA. Seaweeds: A sustainable
functional food for complementary and alternative therapy. Trends
Food Sci Technol 2012;23:83-96.
Matanjun P, Mohamed S, Muhammad K, Mustapha NM. Comparison
of cardiovascular protective effects of tropical seaweeds, Kappaphycus
Asian J Pharm Clin Res, Vol 9, Issue 1, 2016, 168-170
Daud et al.
alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on highcholesterol/high-fat
diet in rats. J
Med
Food 2010;13(4):792-800.
Sachdewa A, Khemani LD. A preliminary investigation of the possible
hypoglycemic activity of Hibiscus rosa-sinensis. Biomed Environ Sci
;12(3):222-6.
Shivananda Nayak B, Sivachandra Raju S, Orette FA, Chalapathi
Rao AV. Effects of Hibiscus rosa sinensis L (Malvaceae) on wound
healing activity: A preclinical study in a Sprague Dawley rat. Int J Low
Extrem Wounds 2007;6(2):76-81.
Dwevedi RN, Pandey SP, Tripathi VJ. Role of Hibiscus rosa-sinensis in
the treatment of arterial hypertension. A trial study. J Res Indian Med
Yoga Homeopathy 1977;12:13-36.
Sethi N, Nath D, Singh RK. Teratological study of an indigenous
antifertility medicine, Hibiscus rosa-sinensis in rats. Arogya J Health
Sci 1986;12:86-8.
Karthigeyan K, Sumathi R, Jayanthi J, Diwakar PG, Lakra GS. Piper
sarmentosum Roxb. - An addition to the flora of Andaman Islands. Curr
Sci 2004;87(2):140-1.
Ugusman A, Zakaria Z, Chua K. Flavonoids of Piper sarmentosum
and its cytoprotective effects against oxidative stress. EXCLI J
;11:705-14.
Peungvicha P, Thirawarapan SS, Temsiririrkkul R, Watanabe H, Kumar
Prasain J, Kadota S. Hypoglycemic effect of the water extract of Piper
sarmentosum in rats. J Ethnopharmacol 1998;60(1):27-32.
Zakaria ZA, Patahuddin H, Mohamad AS, Israf DA, Sulaiman MR.
In vivo anti-nociceptive and anti-inflammatory activities of the
aqueous extract of the leaves of Piper sarmentosum. J Ethnopharmacol
;128(1):42-8.
Amran AA, Zakaria Z, Othman F, Das S, Raj S, Nordin NA. Aqueous
extract of Piper sarmentosum decreases atherosclerotic lesions in high
cholesterolemic experimental rabbits. Lipids Health Dis 2010;9:44.
Kumar A, Singh A. Review on Hibiscus rosa-sinensis. Int J Res Pharm
Biomed Sci 2009;3(2):534-8.
Mohd Zainudin M, Zakaria Z, Megat Mohd Nordin NA. The use of Piper
sarmentosum leaves aqueous extract (Kadukmyâ„¢) as antihypertensive
agent in spontaneous hypertensive rats. BMC Complement Altern Med
;15:54.
Kang JY, Khan MN, Park NH, Cho JY, Lee MC, Fujii H, et al.
Antipyretic, analgesic, and anti-inflammatory activities of the
seaweed Sargassum fulvellum and Sargassum thunbergii in mice.
J Ethnopharmacol 2008;116(1):187-90.
Manikandar RV, Rajesh V, Kumar RS, Perumal P, Raj CD. Analgesic
and anti-pyretic activity of stem bark of Prosopis cineraria (Linn).
Druce. J Pharm Res 2009;2(4):660-2.
Botting RM. Mechanism of action of acetaminophen: Is there a
cyclooxygenase 3? Clin Infect Dis 2000;31 Suppl 5:S202-10.
Hämäläinen M, Nieminen R, Asmawi MZ, Vuorela P, Vapaatalo H,
Moilanen E. Effects of flavonoids on prostaglandin E2 production and
on COX-2 and mPGES-1 expressions in activated macrophages. Planta
Med 2011;77(13):1504-11.
Saper CB, Breder CD. The neurologic basis of fever. N Engl J Med
;330(26):1880-6.
Owoyele BV, Oguntoye SO, Darel K, Alice B. Analgesic, antiinflammatory
and
anti-pyretic activities
from
flavonoids fractions of
Chromolaena
odorata.
J
Med
Plants Res 2008;2(9):219-25.
Hossain E, Mandal SC, Gupta JK. Phytochemical screening and in vivo
antipyretic activity of the methanol leaf extract of Bombax malabaricum
DC (Bombacaceae). Trop J Pharm Res 2011;10(1):55-60.
Muhammad N, Saeed M, Khan H. Antipyretic, analgesic and antiinflammatory
activity
of
Viola
betonicifolia
whole plant. BMC
Complement
Altern
Med 2012;12:59.
Krishnaiah D, Devi T, Bono A, Sarbatly R. Studies on phytochemical
constituents of six Malaysian medicinal plants. J Med Plants Res
;3(2):67-72.
Ridtitid W, Ruangsang P, Reanmongkol W, Wongnawa M. Studies
of the anti-inflammatory and antipyretic activities of the methanolic
extract of Piper sarmentosum Roxb. leaves in rats. Songklanakarin J
Sci Technol 2007;29(6):1519-26.
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