TY - JOUR AU - Sharma, Shivam AU - Mehta, Vineet AU - Sharma, Parul AU - Jaggi, Kritika AU - Udayabanu, Malairaman AU - Sood, Hemant PY - 2018/11/07 Y2 - 2024/03/28 TI - ANTIFERTILITY ACTIVITY AND CONTRACEPTIVE POTENTIAL OF THE HYDROALCOHOLIC RHIZOME EXTRACT OF TRILLIUM GOVANIANUM IN FEMALE WISTAR RATS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 11 IS - 11 SE - Original Article(s) DO - 10.22159/ajpcr.2018.v11i11.27420 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/27420 SP - 329-332 AB - <p class="Pa7"><strong><span>Objective: </span></strong><em><span>Trillium govanianum </span></em><span>is used in several traditional containing steroids and sex hormones for the management of inflammation, menstrual disorders, sex-related disorders, and antiseptic. The present study was aimed to investigate the antifertility potential of hydroalcoholic rhizome extract of <em>T. govanianum </em>and to explore the possible mechanism of action. </span></p><p class="Pa7"><strong><span>Methods: </span></strong><span>Anti-implantation activity of <em>T. govanianum </em>rhizome extract (125 and 250 mg/kg; p.o.) was performed in female Wistar rats with proven fertility, and its estrogenic/antiestrogenic effect was evaluated in ovariectomized females. 17-α-ethinylestradiol (1 μg/rat/day; s.c.) or plant extract was administered for 11 days after which animals were sacrificed. Percentage inhibition of implantation sites, serum estrogen levels, changes in body and uterus weight, and morphological alterations in the uterus and ovaries were evaluated. </span></p><p class="Pa7"><strong><span>Results: </span></strong><em><span>T. govanianum </span></em><span>treatment resulted in increased uterus weight and induced dose-dependent anti-implantation effect, with 100% implantation inhibition at 250 mg/kg dose. Anti-implantation effects of <em>T. govanianum </em>were associated with endometrial thickening and significantly elevated serum estrogen levels. Moreover, estrogenic/antiestrogenic studies revealed that <em>T. govanianum </em>possessed strong estrogenic effect; however, the effect was saturable. </span></p><p class="Pa7"><strong><span>Conclusion: </span></strong><em><span>T. govanianum </span></em><span>possesses antifertility activity which can be attributed to its strong estrogenic potential and uterine thickening. Moreover, it could find a clinical application as a safer and efficacious birth control herbal remedy.</span></p> ER -