1Amity Institute of Pharmacy, Amity University Gomti Nagar Extention, Lucknow UP, 226028 India, 2Deputy Director, Amity Institute of Pharmacy, Amity University, Gomti Nagar Extention, Lucknow UP, 226028 India, 3Pharmacy Department Integral University, Lucknow UP 226026 India
Objective: The present study was planned to develop thermoreversible in-situ gel for the treatment of allergic rhinitis (AR). The objective of the present investigation was to develop a mucoadhesive in-situ gel with reduced nasal mucociliary clearance to improve the local effect of the polyherbal extract in the treatment of allergic rhinitis (AR). The prolonged residence of the drug formulation in the nasal cavity is one of utmost importance for intranasal drug delivery. The prepared formulations were subjected for gelling temperature, gelling time, viscosity, gel strength, pH, drug content, mucoadhesive strength, spreadability and irritancy studies.
Methods: In the study, the pluronic F127 (PF127) based mucoadhesive in-situ nasal gels containing Moringa olifera (MO) and Embelia ribes (ER) extracts were used having an antioxidant and anti-inflammatory effect. A polyherbal thermosensitive in-situ hydrogel was designed and evaluated by the mixing of pluronic F127, poly (ethylene glycol) (PEG400) and Xanthan gum with a small amount of (hydroxypropyl methylcellulose) HPMC K4M and Carbopol 934. Total 13 thermosensitive in-situ gels of extracts were prepared through a combination of HPMC K4M or Carbopol or xanthan gum and PF127. All the preparations were investigated, and the selected method for gel formation underwent the thermal transition from sol to the hydrogel.
Results: The mucoadhesive gel after being administered into the nasal cavity, get transformed into the viscous hydrogel at body temperature, which diminished nasal mucociliary clearance and prolonged the duration of action. The in-situ nasal herbal gel prepared by a combination of the different concentration of to HPMC K4M or carbopol or xanthan gum with PF127 (10% w/v) produces the better and effective gel. The findings of evaluation parameter indicate that the in-situ gel prepared by combination with corbopol were better quality compared to HPMC K4M and xanthan gum.
Conclusion: From these findings, it can be concluded that in-situ herbal nasal gels may be potential drug delivery systems for Moringa olifera and Embelia ribes extracts to overcome the first-pass metabolism and thereby to improve the bioavailability. The mucoadhesive in-situ gel system is a promising approach for the intranasal delivery of polyherbal extracts for the therapeutic effects improvement of Allergic rhinitis.
Keywords: Moringa olifera, Embelia ribes, HPMC, Carbopol, In-situ, Pluronic F127
Erratum of the manuscript no 18780 published in October 2017 issue.
RICHA SRIVASTAVA1, SAJAL SRIVASTAVA2, SATYA PRAKASH SINGH3
1Amity Institute of Pharmacy, Amity University Gomti Nagar Extention, Lucknow UP, 226028 India,
2Deputy Director, Amity Institute of Pharmacy, Amity University, Gomti Nagar Extention, Lucknow UP, 226028 India,
3Pharmacy Department Integral University, Lucknow UP 226026 India.
NEW CORRECTED AFFILIATION
RICHA SRIVASTAVA1, SAJAL SRIVASTAVA1*, SATYA PRAKASH SINGH2.
1Amity Institute of Pharmacy, Amity University Uttar Pradesh Lucknow campus. 226028 India.
2Department of Pharmacy Integral University, Lucknow UP 226026 India.