SIMPLE DESIGN OF MINIATURIZED CABINET FOR COMPOUNDING VITAMIN C EFFERVESCENT TABLET IN LABORATORY SCALE
Keywords:Compounding, Cabinet, Effervescent, Miniaturized, Relative humidity, Control
Objective: The aim of this study was to design miniaturized cabinet that needs the tight requirements in formulating the ingredients of the effervescent tablets to minimize the relative humidity value in order to prevent the initial effervescent reaction.
Methods: The compounding workspace was created by designing cabinet arranged with special equipment so that the humidity and temperature of the mixing chamber could be monitored. The conditioning of the workspace was carried out using a variety of methods ie lights, active silica gel and a combination of both during certain observation times. In this study, all of the components in the effervescent tablet formula were mixed using two steps of the wet granulation method. The evaluation of effervescent tablets included: the appearance of the tablet, diameter, tablet thickness, weight uniformity, hardness, friability, tablet disintegration time, pH of the solution, and hedonic test.
Results: The results of moisture control optimization indicated that the most rapid method of lowering moisture was using a combination of active light and silica gel. After 100 min, this method could decreased the relative humidity (RH) by 0.415% per min. Based on the evaluation results, all formulas achieved the requirements of good effervescent tablets.
Conclusion: In this research, the design of compounding cabinets with dimensions of 60x40x59.5 cm was proven to produce effervescent tablets that fulfill the requirements.
Li Y, Schellhorn HE. New developments and novel therapeutic perspectives for vitamin C. J Nutr 2007;137:2171-84.
Jacob RA, Sotoudeh G. Vitamin C function and status in chronic disease. Nutr Clin Care 2002;5:66-74.
Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 1999;69:1086-107.
Weinstein M, Babyn P, Zlotkin S. An orange a day keeps the doctor away: scurvy in the year 2000. Pediatrics 2001;108:55.
Institute of Medicine. Food and nutrition board. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academy Press, Washington DC; 2000.
Maximiano FP, Costa GHY, Sa-Barreto LCL, Bahia MT, Cunha F. Development of effervescent tablets containing benznidazole complexed with cyclodextrin. J Pharm Pharmacol 2011;63:786-93.
Robert LE. Amerilab technologies, Effervescent tablets., CSC publishing. Available from: https://www.amerilabtech.com/ wp-content/uploads/2012/01/EffervescentTabletsKeyFacts. pdf [Last accessed on 20 Jan 2018].
Prabhakar CH, Krishna KB. A review on effervescent tablets. Int J Pharm Technol 2011;3:704-12.
Kabir AK, Huda NH, Jhanker YM, Shamin K. Formulation development of verapamil hydrochloride tablet by effervescent method. S J Pharm Sci 2010;3:34-7.
Wadhwani AR, Prabhu NB, Nandkarni MA, Amin PD. Consumer friendly mucolytic formulations. Indian J Pharma Sci 2004;7:506-7.
Liberman HA, Lachman L, Schwartz JB. Pharmaceutical dosage forms: tablets. 2nd ed. Marcel Dekker Inc, New York; 1989.
Wells ML, Wood DL, Sanftleben R, Shaw K, Hottovy J, Weber T, et al. Potassium carbonate as a desiccant in effervescent tablets. Int J Pharm 1997;152:227-35.
Jacob S, Shirwaikar A, Nair A. Preparation and evaluation of fast-disintegrating effervescent tablets of glibenclamide. Drug Dev Ind Pharm 2009;35:321-8.
Rajalakshmi G, Vamsi CH, Balachandar R, Damodharan N. Formulation and evaluation of diclofenac potassium effervescent tablets. Int J Pharm Biomed Res 2011;2:237-43.
Swarbrick J. Encyclopedia of pharmaceutical technology. 5th ed. Marcel Dekker, Inc, New York; 1988.
Aslani A, Eatesam P. Design, formulation and physicochemical evaluation of acetaminophen effervescent tablets. J Rep Pharma Sci 2013;2:140-9.
Mohrle R. Effervescent Tablets. Pharmaceutical Dosage Forms. 1st ed. Marcel Dekker, Inc, New York; 1989.
Amela J, Salazar R, Cemelli J. Effervescent tablets of ascorbic acid. I. physical sudy of the possible components to be used. Drug Dev Ind Pharm 1996;22:407-16.
Aslani A, Fattahi F. Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets. Adv Pharm Bull 2013;3:217-25.
Aslani A, Daliri A. Design, formulation and evaluation of its physiochemical properties of acetaminophen, ibuprofen and caffeine as effervescent tablet. J Rep Pharma Sci 2016;5:122-34.
Patel AA, Parikh RH, Mehta TA. Development optimization and evaluation of effervescent tablets of chlorpheniramine maleat using box behnken design. Int J Pharm Pharm Sci 2015;7:317-23.
Cunha Filho MSS, Gustmann PC, Garcia FS, Lima EM, Sa-Barreto LCL. Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design. Braz J Pharm Sci 2014;50:244-6.
Shaikh S, Khirsagar RV, Quazi A. Fast disintegrating tablets: an overview of formulation and technology. Int J Pharm Pharm Sci 2010;2:9-15.
Yanze FM, Duru C, Jacob M. A process to produce effervescent tablets: fluidized bed dryer melt granulation. Drug Dev Ind Pharm 2000;26:1167-76.