CHARACTERIZATION OF HYDROXYPROPYL CELLULOSE PRODUCED FROM α-CELLULOSE BETUNG BAMBOO (DENDROCALAMUS ASPER) AND IT’S APPLICATION IN TABLET FORMULATION

Authors

  • Herman Suryadi Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Harmita . Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Muhammad Herpi Akbar Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Pingkan Lestari Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Pingkan Lestari Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia

DOI:

https://doi.org/10.22159/ijap.2019v11i2.31078

Keywords:

Betung bamboo, Characterization, Hydroxypropyl cellulose, Tablet

Abstract

Objective: This study aimed to obtain the physicochemical properties of hydroxypropyl cellulose (HPC) powder from α-cellulose Betung bamboo and its characteristics in tablet formulation.

Methods: HPC was prepared by hydroxypropylation of α-cellulose using 25% (w/v) sodium hydroxide and 10 ml propylene oxide (based on 1 g α-cellulose) at 70 °C for 3 h. HPC of Betung bamboo (HPC BB) was characterized using fourier transform infrared (FTIR) spectrometry, particle size analyzer (PSA), x-ray diffraction (XRD), scanning electron microscope (SEM) and compared to HPC grade SL (HPC SL) as the reference. Then, HPC BB was used as a binder in tablet formulation by direct compression method and the resulted tablets were evaluated. The tablets evaluation including weight and size uniformity, hardness, friability and disintegration time.

Results: The results showed HPC BB powder was yellowish white, odorless and tasteless, pH 7.49, residue on ignition 0.68%, hydroxypropoxy groups content 54.75%, average particle size 37.39 μm, loss on drying 1.09%, and moisture content 3.34%. Flow properties of powder fulfilled the requirements based on literature. Infrared spectrum and diffraction pattern of HPC BB were relatively similar to HPC SL. The tablets have average weight 403.495 mg, diameter 12.16 mm, thickness 3.11 mm, hardness 4.11 KPa, friability 2.04% and disintegration time 24.88 s.

Conclusion: Based on the comparison of powder characteristics and tablets evaluation, HPC BB has a great potential in tablet formulation which showed similar characteristics to reference.

Downloads

Download data is not yet available.

References

Rowe RC, Sheskey PJ, Quinn ME. editors. Handbook of Pharmaceutical Excipients 6th Ed. Grayslake and Washington DC: American Pharmacist Association and Pharmaceutical Press; 2009.

Santos EM. Final report on the safety assessment of hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxypropyl methylcellulose, and cellulose gum. Int J Toxicol 1986;5:1-59.

Wustenberg T. Cellulose and cellulose derivatives in the food industry: Fundamentals dan Applications. Weinheim: Wiley-VCH; 2012.

Mosier N, Wyman C, Dale B, Elander R, Lee Y, Holtzapple M. Features of promising technologies for pretreatment of lignocellulosic biomass. Bioresour Technol 2005;96:673-86.

Chuayjuljit S, Su-Uthai S, Charuchinda S. Poly(vinyl chloride) film filled with microcrystalline cellulose prepared from cotton fabric waste: properties and biodegradability study. Waste Manage Res 2010;28:109-17.

Fengel D, Wegner G. Wood: Chemistry, Ultrastructure, Reaction. Berlin and New York: Walter de Gruyter; 1984.

Abdel Halim ES, Alanazi HH, Al-Deyab SS. Utilization of olive tree branch cellulose in the synthesis of hydroxypropyl carboxymethyl cellulose. Carbohydr Polym 2015;127:124-34.

Riviani E. Synthesis and characterization of hydroxypropyl cellulose (HPC) snake fruit (Salacca edulis Reinw) pondoh super kernel [Sintesis dan Karakterisasi hydroxypropyl cellulose (HPC) dari biji salak (Salacca edulis Reinw) Pondoh Super]. Thesis. Yogyakarta: Universitas Gadjah Mada; 2016.

Sharma R, Varshney VK, Chauhan GS. Hydroxypropylation of cellulose isolated from bamboo (Dendrocalamusstrictus) with respect to hydroxypropoxyl content and rheological behavior of the hydroxypropyl cellulose. J Appl Polym Sci 2009;113:2450-5.

Kharismi RRAY, Sutriyo, Suryadi H. Preparation and characterization of microcrystalline cellulose produce from betung bamboo (Dendrocalamus asper) through acid hydrolysis. J Young Pharm 2018;10:79-83.

Hutomo GS. Synthesis and characterization of cellulose derivate from pod husk kakao (Theobrome cacao L.)[Sintesis dan Karakterisasi Turunan Selulosa dari Pod Husk Kakao (Theobrome cacao L.)]. Dissertation. Yogyakarta: Universitas Gadjah Mada; 2012.

Johnson DP. Spectrophotometric determination of the hydroxypropyl group in starch ethers. J Anal Chem 1969;41:859.

British Pharmacopoeia Commission. British Pharmacopoeia 2008. London: Stationery Office; 2008.

United States Pharmacopoeial Convention. The United States Pharmacopeia (USP) 37–NF 32. Hydroxypropyl Cellulose monograph. Rockville: The United States Pharmacopoeial Convention; 2014.

United States Pharmacopoeial Convention. The United States Pharmacopeia (USP) 38–NF 33. Bulk Density and Tapped Density of Powders. Rockville: The United States Pharmacopoeial Convention; 2015.

United States Pharmacopoeial Convention. The United States Pharmacopeia (USP) 35–NF 30. Powder Flow. Rockville: The United States Pharmacopoeial Convention; 2011.

Suryadi H, Sutriyo, Sari HS, Rosikhoh D. Preparation of microcrystalline cellulose from water hyacinth powder by enzymatic hydrolysis using cellulase of local isolate. J Young Pharm 2017;9:19-23.

Niazi SK. Handbook of pharmaceutical manufacturing formulations: compressed solid products. 2nd Ed. New York: Informa Healthcare; 2009.

Kim S, Limpongsa E, Jaipakdee N. Effects of formulation parameters on properties of gastric floating tablets containing poorly soluble drug: diclofenac sodium. Int J Appl Pharm 2018;10:152-60.

Ohwoavworhua FO, Adelakun TA, Okhamafe AO. Processing pharmaceutical grade microcrystalline cellulose from groundnut husk: extraction methods and characterization. Int J Green Pharm 2009;3:97-104.

Published

07-03-2019

How to Cite

Suryadi, H., ., H., Akbar, M. H., Lestari, P., & Lestari, P. (2019). CHARACTERIZATION OF HYDROXYPROPYL CELLULOSE PRODUCED FROM α-CELLULOSE BETUNG BAMBOO (DENDROCALAMUS ASPER) AND IT’S APPLICATION IN TABLET FORMULATION. International Journal of Applied Pharmaceutics, 11(2), 123–129. https://doi.org/10.22159/ijap.2019v11i2.31078

Issue

Section

Original Article(s)

Most read articles by the same author(s)

<< < 1 2 3 > >>