• Gurpreet Kandav Department of Pharmaceutical sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana- 125001, India.
  • D.c. Bhatt Department of Pharmaceutical sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana- 125001, India.
  • Deepak Kumar Jindal Department of Pharmaceutical sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana- 125001, India.



Allopurinol, Sustained release, Chitosan, Nanoparticles


Objective: The objective of the present investigation was to fabricate and characterize allopurinol loaded chitosan nanoparticles (A-CNPs) for sustained release of drug.

Methods: The allopurinol loaded chitosan nanoparticles were successfully prepared by employing the ionotropic gelation method. Further, particle size (PS), polydispersity index (PDI), zeta potential (ZP), Differential Scanning Calorimetry (DSC), entrapment efficiency (EE), Transmission Electron Microscopy (TEM), in vitro drug release, X-Ray Diffraction (XRD) and Fourier transform infrared (FTIR) were used for evaluating formulated A-CNPs

Results: A-CNPs was successfully prepared and the particle size, polydispersity index, ZP and entrapment efficiency were found to be 375.3±10.1 nm, 0.362±0.01 and 32.5±2.7 mV and 52.56±0.10% respectively. In vitro release profile of A-CNPs showed sustained release and Higuchi model was found to be best fit for drug release kinetics. FTIR study depicted no chemical interaction between pure drug allopurinol (AL) and other excipients.

Conclusion: The sustained release formulation of allopurinol was successfully prepared using HMW chitosan and evaluated for different parameters.


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How to Cite

Kandav, G., Bhatt, D., & Jindal, D. K. (2019). FORMULATION AND EVALUATION OF ALLOPURINOL LOADED CHITOSAN NANOPARTICLES. International Journal of Applied Pharmaceutics, 11(3), 49–52.



Original Article(s)