MICROFLUIDIC DEVICES AS A TOOL FOR DRUG DELIVERY AND DIAGNOSIS: A REVIEW

Authors

  • ISHA SHARMA Department of Applied Sciences and BiotechnologyShoolini University, Vill-BhajholSolan, Himachal Pradesh, India, 173229
  • MONIKA THAKUR Department of Applied Sciences and BiotechnologyShoolini University, Vill-BhajholSolan, Himachal Pradesh, India, 173229
  • SHAVETA SINGH Department of Applied Sciences and BiotechnologyShoolini University, Vill-BhajholSolan, Himachal Pradesh, India, 173229
  • ASTHA TRIPATHI Department of Applied Sciences and BiotechnologyShoolini University, Vill-BhajholSolan, Himachal Pradesh, India, 173229

DOI:

https://doi.org/10.22159/ijap.2021v13i1.39032

Keywords:

Microfluidic drug delivery system, Circulating tumor cells, Cancer diagnosis, Lab on chip

Abstract

Microfluidic devices are a good example of the collaboration of chemical, biological, and engineering sciences. Microfluidic devices emerge as an in fluent technology which provides an alternative to conventional laboratory methods. These devices are employed for the precise handling and transport precise quantities of drugs without toxicity. This system is emerging as a promising platform for designing advanced drug delivery systems and analysis of biological phenomena on miniature devices for easy diagnosis. Microfluidics enables the fabrication of drug carriers with controlled geometry and specific target sites. Microfluidic devices are also used for the diagnosis of cancer circulating tumor cells. In the current review, different microfluidic drug delivery systems and diagnostic devices have described.

Downloads

Download data is not yet available.

References

Nasseri B, Soleimani N, Rabiee N, Kalbasi A, Karimi M, Hamblin MR. Point-of-care microfluidic devices for pathogen detection. BiosenBioelectr 2018;117:112-28.

Nithya TG, Sumalatha D. Evaluation of in vitro antioxidant and anticancer activity of Coriandrumsativum against human colon cancer HT-29 cell lines. Int J Pharm PharmSci 2014;6:421-4.

Chung MJ, Chung CK, Jeong Y, Ham SS. Anticancer activity of subfractions containing pure compounds of chaga mushroom (Inonotusobliquus) extract in human cancer cells and in Balbc/c mice bearing sarcoma-180 cells. Nutr Res Pract 2010;4:177–82.

Bednarz Knoll N, AlixPanabieres C, Pantel K. Clinical relevance and biology of circulating tumor cells. Breast Cancer Res 2011;13:228.

Perez Gonzalez VH, Gallo Villanueva RC, Camacho Leon S, Gomez Quinones JI, Rodriguez Delgado JM, Martinez Chapa SO. Emerging microfluidic devices for cancer cells/biomarkers manipulation and detection. IET Nanobiotechnol 2016;10:263-75.

Chung AJ, Kim D, Erickson D. Electrokinetic microfluidic devices for rapid, low power drug delivery in autonomous microsystems. Lab Chip 2008;8:330-8.

Lin CC, Anseth KS. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res 2009;26:631-43.

Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomed 2015;10:975.

Lee TY, Choi TM, Shim TS, Frijns RA, Kim SH. Microfluidic production of multiple emulsions and functional microcapsules. Lab Chip 2016;16:3415-40.

Wang F, Wang H, Wang J, Wang HY, Rummel PL, Garimella SV, et al. Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing. BiotechnolBioeng 2008;100:150-8.

Kwak TJ, Nam YG, Najera MA, Lee SW, Strickler JR, Chang WJ. Convex grooves in staggered herringbone mixer improve mixing efficiency of laminar flow in microchannel. PloSOne 2016;11:e0166068.

Damiati S, Kompella UB, Damiati SA, Kodzius R. Microfluidic devices for drug delivery systems and drug screening. Genes 2018;9:103.

Lee TY, Choi TM, Shim TS, Frijns RA, Kim SH. Microfluidic production of multiple emulsions and functional microcapsules. Lab Chip 2016;16:3415-40.

Li Y, Yamane DG, Li S, Biswas S, Reddy RK, Goettert JS, et al. Geometric optimization of liquid-liquid slug flow in a flow-focusing millifluidic device for synthesis of nanomaterials. ChemEng J 2013;217:447-59.

Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: a smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother 2019;109:1249-58.

Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Delivery Rev 2012;64:1547-68.

Chen J, Li J, Sun Y. Microfluidic approaches for cancer cell detection, characterization, and separation. Lab Chip 2012;12:1753-67.

Kim S, Han SI, Park MJ, Jeon CW, Joo YD, Choi IH, et al. Circulating tumor cell microseparator based on lateral magnetophoresis and immunomagneticnanobeads. Anal Chem 2013;85:2779-86.

Riethdorf S, Fritsche H, Müller V, Rau T, Schindlbeck C, Rack B, et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the cell search system. Clin Cancer Res 2007;13:920-8.

Kulasinghe A, Wu H, Punyadeera C, Warkiani ME. The use of microfluidic technology for cancer applications and liquid biopsy. Micromachines 2018;9:397.

Fabbri F, Carloni S, Zoli W, Ulivi P, Gallerani G, Fici P, et al. Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs. Cancer Lett 2013;335:225-31.

He JH, Reboud J, Ji HM, Lee C, Long Y. Development of microfluidic device and system for breast cancer cell fluorescence detection. J Vacuum SciTechnolB: Microelectr Nanometer Structures Process MeasurPhenom 2009;27:1295-8.

Chung J, Reiner SH,Issadore T,Weissleder D, Lee H. Microflfluidic cell sorter (MUFCS) for on-chip capture and analysis of single cells. AdvHealthc Mater2012;1:432–6.

Rosenberg R, Gertler R, Friederichs J, Fuehrer K, Dahm M, Phelps R, et al. Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in blood. Cytometry2002;49:150–8.

KałużnaCzaplinska J, Jozwik J. Current applications of chromatographic methods for diagnosis and identification of potential biomarkers in cancer. TrendsAnal Chem 2014;56:1-2.

Chen H, Hou Y, Qi F, Zhang J, Koh K, Shen Z, et al. Detection of vascular endothelial growth factor based on rolling circle amplification as a means of signal enhancement in surface plasmon resonance. BiosensBioelectr 2014;61:83-7.

Piliarik M, Bockova M, Homola J. Surface plasmon resonance biosensor for parallelized detection of protein biomarkers in diluted blood plasma. BiosensBioelectr 2010;26:1656-61.

Sanders M, Lin Y, Wei J, Bono T, Lindquist RG. An enhanced LSPR fiber-optic nanoprobe for ultrasensitive detection of protein biomarkers. BiosensBioelectron 2014;61:95-101.

Ladd J, Taylor AD, Piliarik M, Homola J, Jiang S. Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging. Anal BioanalChem 2009;393:1157-63.

Li R, Feng F, Chen ZZ, Bai YF, Guo FF, Wu FY, et al. Sensitive detection of carcinoembryonic antigen using surface plasmon resonance biosensor with gold nanoparticles signal amplification. Talanta 2015;140:143-9.

Geng Z, Kan Q, Yuan J, Chen H. A route to low-cost nanoplasmonic biosensor integrated with the optofluidic-portable platform. SensActuaB: Chem 2014;195:682-91.

Zhang K, Zhao LB, Guo SS, Shi BX, Lam TL, Leung YC, et al. A microfluidic system with surface modified piezoelectric sensor for trapping and detection of cancer cells. BiosensBioelectr 2010;26:935-9.

He JH, Reboud J, Ji HM, Lee C, Long Y. Development of microfluidic device and system for breast cancer cell fluorescence detection. J Vacuum SciTechnolB: Microelectr Nanometer Structures Process MeasurPhenom 2009;27:1295-8.

Dizdar L, Fluegen G, Van Dalum G, Honisch E, Neves RP, Niederacher D, et al. Detection of circulating tumor cells in colorectal cancer patients using the GILUPI cell collector: results from a prospective, single‐center study. MoleculOncol 2019;13:1548-58.

Hur SC, Di Carlo D. Passive label-free rare cell enrichment inertial microfludic device using cell deformability as a biomarker. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences;2010.

Ko J, Carpenter E, Issadore D. Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices. Analyst 2016;141:450-60.

Aftab A, Bashir S, Rafique S, Ghani T, Khan R, Bashir M, et al. Microfluidic platform for encapsulation of plant extract in chitosan microcarriers embedding silver nanoparticles for breast cancer cells. ApplNanosci 2020;10:2281–93.

Zhu C, Yang H, Shen L, Zheng Z, Zhao S, Li Q, et al. Microfluidic preparation of PLGA microspheres as cell carriers with sustainable rapa release. J Biomaterials Sci Polymer Edi 2019;30:737-55.

Wan S, Kim TH, Smith KJ, Delaney R, Park GS, Guo H, et al. New labyrinth microfluidic device detects circulating tumor cells expressing cancer stem cell marker and circulating tumor microemboli in hepatocellular carcinoma. Sci Reports 2019;9:18575.

Su W, Yu H, Jiang L, Chen W, Li H, Qin J. Integrated microfluidic device for enrichment and identification of circulating tumor cells from the blood of patients with colorectal cancer. Disea Markers 2019. DOI:10.1155/2019/8945974

Liao CJ, Hsieh CH, Chiu TK, Zhu YX, WangHM, Hung FC, et al. An optically induced dielectrophoresis (ODEP)-based microfluidic system for the isolation of high-purity CD45neg/EpCAMneg cells from the blood samples of cancer patients-demonstration and initial exploration of the clinical significance of these cells. Micromac 2018;9:563.

Cheng SB, Xie M, Chen Y, Xiong J, Liu Y, Chen Z, et al. Three-dimensional scaffold chip with thermosensitive coating for capture and reversible release of individual and cluster of circulating tumor cells. Anal Chem 2017;89:7924-32.

Xu G, Tan Y, Xu T, Yin D, Wang M, Shen M, et al. Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture.BiomaterSci 2017;5:752-61.

Li Z, Wang G, Shen Y, Guo N, Ma N. DNA‐templated magnetic nanoparticle‐quantum dot polymers for ultrasensitive capture and detection of circulating tumor cells. AdvFunct Materials 2018;28:1707-152.

Zou D, Cui D. Advances in isolation and detection of circulating tumor cells based on microfluidics. Cancer Bio Med 2018;15:335.

Pritchard JF, JurimaRomet M, Reimer ML, Mortimer E, Rolfe B, Cayen MN. Making better drugs: decision gates in non-clinical drug development. Nature Rev Drug Discovery 2003;2:542-53.

Esch EW, Bahinski A, Huh D. Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discovery 2015;14:248-60.

Soldatow VY, LeCluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. ToxicolResear 2013;2:23-39.

Fitzgerald KA, Malhotra M, Curtin CM, O'Brien FJ, O'Driscoll CM. Life in 3D is never flat: 3D models to optimise drug delivery. J Controlled Release 2015;215:39-54.

Lee SH, Sung JH. Organ-on-a-chip technology for reproducing multiorgan physiology. Adv Healthcare Mater 2018;7:1700419.

Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG. Bioreactor technologies to support liver function in vitro. Adv Drug Delivery Rev 2014;69:132-57.

Sung JH, Esch MB, Prot JM, Long CJ, Smith A, Hickman JJ, et al. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 2013;13:1201-12.

Kimura H, Sakai Y, Fujii T. Organ/body-on-a-chip based on microfluidic technology for drug discovery. Drug MetabolPharmacokinet 2018;33:43-8.

Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, et al. A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice. SciTransl Med 2012;4:159.

Ashammakhi N, WesselingPerry K, Hasan A, Elkhammas E, Zhang YS. Kidney-on-a-chip: untapped opportunities. Kidney Intern 2018;94:1073-86.

Conant G, Lai BF, Lu RX, Korolj A, Wang EY, Radisic M. High-content assessment of cardiac function using heart-on-a-chip devices as drug screening model. Stem Cell Rev Reports 2017;13:335-46.

Zheng F, Fu F, Cheng Y, Wang C, Zhao Y, Gu Z. Organ-on-a-chip systems: microengineering to biomimic living systems. Small 2016;12:2253-82.

Sandia National Laboratories, SUMMiT* Technologies. Available from:http://www.mems.sandia.gov [Last accessed on 10 Jun 2020]

Razzacki SZ, Thwar PK, Yang M, Ugaz VM, Burns MA. Integrated microsystems for controlled drug delivery. Adv Drug Delivery Rev 2004;56:185-98.

Kumar S, Shanmugasundaram P, Komala M,Bhargavi B, Padmavathy J. Nanoparticle formulation of bioflavonoids for enhanced anti cancer activity. Int J App Pharm 2020;20:29-35.

Ranjan P. Investigations on the flow behaviour in microfluidic device due to surface roughness: a computational fluid dynamics simulation. Microsystem Technol 2019;25:3779-89.

Azizipour N, Avazpour R, Rosenzweig DH, Sawan M, Ajji A. Evolution of biochip technology: a review from lab-on-a-chip to organ-on-a-chip. Micromachines 2020;11:599.

Saliba J, Daou A, Damiati S, Saliba J, El-Sabban M, Mhanna R. Development of microplatforms to mimic the in vivo architecture of CNS and PNS physiology and the diseases. Genes 2018;9:285.

Hafeman DG, Zhou A.Inventors:Caliper Life Sciences Inc, assignee. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels. United States patent US 7,252,928; 2007.

Jang K, Xu Y, Sato K, Tanaka Y, Mawatari K, Kitamori T. Micropatterning of biomolecules on a glass substrate in fused silica microchannels by using photolabile linker-based surface activation. MicrochimicaActa 2012;179:49-55.

Wong I, Ho CM. Surface molecular property modifications for poly (dimethylsiloxane)(PDMS) based microfluidic devices. Microfluidics Nanofluidics 2009;7:291.

EsmaeiliKhoshmardan H, AskariMoghadam R. Enhancing capillary force in glass microfluidic devices for bioengineering applications. J Bioengineering Res 2019;1:19-28.

Kleinstreuer C, Koo J. Computational analysis of wall roughness effects for liquid flow in micro-conduits. J Fluids Eng 2004;126:1-9.

Mukhopadhyay R. When microfluidic devices go bad. In: Analytical chemistry. American chemical society; 2005. p. 429.

Zhang H, Chiao M. Anti-fouling coatings of poly (dimethylsiloxane) devices for biological and biomedical applications. J Med Bio Eng 2015;35:143-55.

Ren K, Zhou J, Wu H. Materials for microfluidic chip fabrication. AccChem Res 2013;46:2396-406.

Plecis A, Chen Y. Fabrication of microfluidic devices based on glass–PDMS–glass technology. MicroelectrEng 2007;84:1265-9.

McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJ, et al. Fabrication of microfluidic systems in poly (dimethylsiloxane). Electrophoresis: An Intern J 2000;21:27-40.

Tsao CW. Polymer microfluidics: simple, low-cost fabrication process bridging academic lab research to commercialized production. Micromachines 2016;7:225.

Focaroli S, Mazzitelli S, Falconi M, Luca G, Nastruzzi C. Preparation and validation of low-cost microfluidic chips using a shrinking approach. Lab Chip 2014;14:4007-16.

Cate DM, Adkins JA, Mettakoonpitak J, Henry CS. Recent developments in paper-based microfluidic devices. Anal Chem 2015;87:19-41.

Johnson BD, Beebe DJ, Crone WC. Effects of swelling on the mechanical properties of a pH-sensitive hydrogel for use in microfluidic devices. Microfluidic Devices Bioapplications 2011;7:12-48.

Published

07-01-2021

How to Cite

SHARMA, I., THAKUR, M., SINGH, S., & TRIPATHI, A. (2021). MICROFLUIDIC DEVICES AS A TOOL FOR DRUG DELIVERY AND DIAGNOSIS: A REVIEW. International Journal of Applied Pharmaceutics, 13(1), 95–102. https://doi.org/10.22159/ijap.2021v13i1.39032

Issue

Section

Review Article(s)