NOVEL FLOATING AGENT SACCHAROMYCES BOULARDII FORMULATION BASED FLOATING DRUG DELIVERY SYSTEM
DOI:
https://doi.org/10.22159/ijap.2021v13i5.42237Keywords:
Saccharomyces boulardii, Probiotics, Furosemide, Response surface methodology, BloatingAbstract
Objective: The objective is to design and optimize a floating tablet of furosemide using a novel floating agent Saccharomyces boulardii.
Methods: In this study floating tablet based on principle of combination of floating and swelling prepared by direct compression technique. Saccharomyces boulardii probiotics preparation is used as a floating agent due to its bloating property i.e. production of CO2 gas and hydrophilic polymer HPMC E LV 15 used as swellable polymer. Furosemide is a BCS class IV drug selected as model drug which shows pH dependent solubility and permeability and it is better absorbed from the gastric region, hence to improve dissolution and residence at absorption site of such drug, floating drug delivery system is needed. Calcium hydroxide used as pH modifier which increase rate of dissolution of furosemide and also maintain integrity of tablet matrix. Formulation designed and developed using central composite design response surface methodology technique, so as to explore the effect of formulation variables such as amount of Saccharomyces boulardii preparation and calcium hydroxide on floating lag time and % drug release after 12h.
Results: The numerical and graphical optimization technique were used to choose the optimal formulation. Floating lag time was found to be 12.6 min and 88.18% drug release for the optimized formulation. In vivo buoyancy studies depicted that formulation stay more then 6h in stomach.
Conclusion: Study indicate that Saccharomyces boulardii is a promising floating agent, and the formulation containing this novel floating agent is suitable for gastro retention and it increases bioavailability of furosemide.
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Agarbati A, Canonico L, Marini E, Zannini E, Ciani M, Comitini F. Potential probiotic yeasts sourced from natural environmental and spontaneous processed foods. Foods 2020;9:1-25.
Czerucka D, Piche T, Rampal P. Review article: yeast as probiotics–saccharomyces boulardii. Aliment Pharmacol Ther 2007;26:767-78.
Boyle RJ, Roy MRB, Tang ML. Probiotic use in clinical practice: what are the risks?. Am J Clin Nutr 2006;83:1256-64.
Dixit K, Gandhi DN. Biotherapeutic properties of probiotic yeast saccharomyces in fermented dairy products; 2006. Available from: https://www.dairyscience.info/index.php/probiotics/232-yeast-probiotics.html. [Last accessed on 10 Apr 2021]
Sindhu SC, Khetarpaul N. Effect of probiotic fermentation on antinutrients and in vitro protein and starch digestibilities of indigenously developed RWGT food mixture. Nutr Health 2002;16:173-81.
The health benefits of saccharomyces boulardii a yeast that may help with diarrhea and more. Available from: https://www.verywellhealth.com/the-benefits-of-saccharomyces-boulardii-89509. [Last accessed on 10 Apr 2021].
Can probiotics cause side effects? Probiotics are healthful strains of live bacteria and yeast. Taking probiotics can provide a range of benefits, but it can also cause side effects. Available from: https://www.medicalnewstoday.com/articles/323821. [Last accessed on 10 Apr 2021].
Mousa AH, Bakry AM. Efficacy of saccharomyces boulardii metabolism during fermentation of milk fortified with wheat grain juice. Food Sci Technol Res 2019;25:657-65.
Dickinson JR. Carbon metabolism. In: Dickinson JR, Schweizer M. eds. The metabolism and molecular physiology of Saccharomyces cerevisiae. London and Philadelphia PA: Taylor and Francis; 1999. p. 23-24.
Kumar S, Nand A. Formulation, optimization and in vitro evaluation of gastroretentive mucoadhesive microspheres of furosemide. Int J Pharm Pharm Sci 2016;8:392-8.
Meka L, Kesavan B, Kalamata VR, Eaga CM, Bandari S, Vobalaboina V, et al. A design and evaluation of polymeric coated minitablets as multiple unit gastroretentive floating drug delivery systems for furosemide. J Pharm Sci 2009;98:2122-32.
Darandale SS, Vavia PR. Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release. Acta Pharm Sin B 2012;2:509-17.
Patel RC, Keraliya RA, Patel MM, Patel MM, Patel NM. Formulation of furosemide solid dispersion with microcrystalline cellulose for achieve rapid dissolution. J Adv Pharm Technol Res 2010;1:180-9.
Pawar HA, Gharat PR, Dhavale RV, Joshi PR, Rakshit PP. Development and evaluation of gastro retentive floating tablets of an antihypertensive drug-using hydrogenated cottonseed oil. ISRN Pharm 2013;2:1-9.
Aswatha Ram HN, Lachake P, Kaushik U, Shreedhara CS. Formulation and evaluation of floating tablets of liquorice extract. Pharmacogn Res 2010;2:304–8.
Patil MS, Vidyasagar G, Patil VB. Formulation, optimization and evaluation of floating tablets clarithromycin. Int J Pharm Pharm Sci 2015;7:320-6.
Shaikh SA, Shaikh SN, Patel SM, Khalifa MY, Makrani SI, Siddiqi HA, et al. Design expert supported formulation development, mathematical optimization and predictability study of floating tablets of bisoprolol fumarate. Int J Appl Pharm 2021;13:242-8.
Tekade BW, Jadhao UT, Patil SG, Patil VR. Formulation and in vitro evaluation of floating tablets of cefpodoxime proxetil. Int J Curr Pharm Res 2017;9:18-22.
Oussama M, Ghenwa I, Mostafa I, Mais A. Assessment of physicochemical properties of furosemide (40 mg) tablets marketed in Syria. J Chem Pharm Sci 2016;9:2879-81.
Tavakoli N, Varshosaz J, Dorkoosh F, Motaghi S, Tamaddona L. Development and evaluation of a monolithic floating drug delivery system for acyclovir. Chem Pharm Bull 2012;60:172-7.
Tiwari SB, Murthy TK, Pai MR, Mehta PR, Chowdary PB. Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system. AAPS PharmSciTech 2003;4:E31.
Rashmitha V, Madhusudan Rao Y, Pavani S. Formulation and evaluation of fenoverine floating tablets. Asian J Pharm Clin Res 2021;14:175-80.
Siepmann J, Siepmann F. Mathematical modeling of drug delivery. Int J Pharm 2008;364:328-43.
Mohapatra S, Barik B, Kar RK, Sahoo SK, Barik BB. Design, development and optimization of gastro retentive floating tablets of cefixime trihydrate. Asian J Chem 2013;25:7599-606.
Arza RAK, Gonugunta CSR, Veerareddy PR. Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets. AAPS PharmSciTech 2009;10:220-6.
Dios P, Nagy S, Pal S, Pernecker T, Kocsis B, Budan F, et al. Preformulation studies and optimization of sodium alginate-based floating drug delivery system for eradication of Helicobacter pylori. Eur J Pharm Biopharm 2015;96:196-206.
Punitha S, Uvarani R, Panneerselvam A. Effect of pH in aqueous (Hydroxy Propyl Methyl Cellulose) polymer solution. Results Materials 2020;100120:1-6.
Chi LL, Luigi GM, James L, Ford MR. The use of hypromellose in oral drug delivery. J Pharm Pharmacol 2005;57:533-46.
Bashar M Al-Taani, Bassam M Tashtoush. Effect of microenvironment pH of swellable and erodable buffered matrices on the release characteristics of diclofenac sodium. AAPS PharmSciTech 2003;4:1-6.
Acharya S, Patra S, Panib NP. Optimization of HPMC and carbopol concentrations in non-effervescent floating tablet through factorial design. Carbohydrate Polymers 2014;102:360-8.
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