MELOXICAM SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM: FORMULATION AND RELEASE KINETICS ANALYSIS

SALMA AULIA; LINA WINARTI; YUDI WICAKSONO

doi:10.22159/ijap.2021.v13s4.43856

Authors

SALMA AULIA Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jln Kalimantan No. 37 Jember 68121, Indonesia
LINA WINARTI Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jln Kalimantan No. 37 Jember 68121, Indonesia
YUDI WICAKSONO Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jln Kalimantan No. 37 Jember 68121, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021.v13s4.43856

Keywords:

Meloxicam, SNEDDS, The kinetics of release, DDSolver

Abstract

Objective: This study aimed to find the best SNEDDS meloxicam formula and analyze the release kinetics of meloxicam SNEDDS and non-SNEDDS using DDSolver.

Methods: Meloxicam SNEDDS was prepared using sunflower seed oil, Cremophor RH 40 as a surfactant, and polyethylene glycol (PEG) 400 as a co-surfactant.

Results: The best formula obtained subjected to the in vitro dissolution study was analyzed using DDSolver. The study shows one selected formula consists of 10% sunflower seed oil, 70% cremophor RH 40, and 20% PEG 400 with a 20.5 nm±12 nm droplet size. The dissolution study showed that SNEDDS could significantly increase the meloxicam release compared to the non-SNEDDS formulation. The kinetics of meloxicam release from SNEDDS formulations follow the Weibull release model (β = 1.00).

Conclusion: This study concludes that SNEDDS best prepared in sunflower seeds oil: Chremophor RH 40: PEG 400 ratio of 1: 7: 2 and has the potency to increase the solubility and dissolution of meloxicam.

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