@article{NAZWIR_YANUAR_SYAHDI_2020, title={IN SILICO INVESTIGATION OF ECHINODERMATA SECONDARY METABOLITES AS HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) REVERSE TRANSCRIPTASE INHIBITORS}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/37449}, DOI={10.22159/ijap.2020.v12s1.FF006}, abstractNote={<p><strong>Objective</strong>: Human immunodeficiency virus (HIV) targets the immune system and weakens immune surveillance and defenses against infections,<br>leading to acute immunodeficiency syndrome. Recent trends in drug discovery from natural sources emphasize investigations of compounds from<br>marine ecosystems.<br><strong>Methods</strong>: In this study, we compiled a database of chemical compounds from echinoderms and virtually screened for those that inhibit HIV-1 reverse<br>transcriptase (RT). The database was generated from literature searches. Virtual screening analyses for inhibitors of HIV-1 RT were then performed<br>using AutoDock software.<br><strong>Results</strong>: Based on screening results, the top thirteen ranked compounds were nobilisidenol B, Ech_005, 17-deoxyholothurinogenin,<br>22,25-oxidoholothurinogenin, Ech_022, Ech_026, Ech_021, nobilisidenol A, Ech_025, 5α-cholest-8(14)-ene-3ß,7α-diol, astropecten A, Ech_004, and<br>phrygiasterol.<br><strong>Conclusion</strong>: The present in silico screening analyses of compounds from marine ecosystems can be used to identify candidate compounds with high<br>potential as drugs for the treatment of refractory HIV infections.</p>}, number={1}, journal={International Journal of Applied Pharmaceutics}, author={NAZWIR, NURRAHMA and YANUAR, ARRY and SYAHDI, REZI RIADHI}, year={2020}, month={Mar.}, pages={51–55} }