TY - JOUR AU - MOHANTY, SUCHISMITA AU - SARANGI, SUBRATA AU - ROY, GOURI SANKAR PY - 2019/05/07 Y2 - 2024/03/29 TI - FORMULATION AND EVALUATION OF GRAPHENE GRAFTED CHITOSAN/POLYANILINE NANOCOMPOSITES FOR CONTROLLED RELEASE OF ANTICANCER DRUG DOXORUBICIN JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 3 SE - Original Article(s) DO - 10.22159/ijap.2019v11i3.31397 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/31397 SP - 138-143 AB - <p><strong>Objective: </strong>The purpose of the present study was to functionalized graphene (f-GE) grafted chitosan (CS)/Polyaniline (PANI) with <em>Montmorillonite</em> (MMT) was different feed ratio known as f-GE-g-(CS/MMT-PANI).</p><p><strong>Methods: </strong>The prepared f-GE-g-(CS/MMT-PANI) was formulated using the solvent casting method. The prepared nanocomposites were characterized by X-Ray Diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Thermogravimetric analysis (TGA), thermogravimetric (DTG) and swelling in stimulated in the different biological fluid. The model drug Doxorubicin (DOX) was used for controlled drug delivery purpose.</p><p><strong>Results: </strong>From FTIR result was clearly demonstrated that the model drug DOX did not change in any molecular level at f-GE-(CS/MMT-PANI) (i.e. at&lt;10 nm scale). Additionally, in DSC result, DOX was interacted with nanocomposites at scale&gt;100 nm level. With CS as the carrier, 60% of the drug was released in SIF for the initial 120 min and this increased to 80–82% with f-GE<em>-g-</em>CS/MMT/PANI matrix. But in SGF, CS as the carrier, 46% of the drug was released in 140 min and this increased to 78% with f-GE<em>-g-</em>CS/MMT/PANI. <em>In vitro</em> drug release system was carried out by Korsmeyer Peppas’s power law. DOX and other drugs like Doxorubicin (DOX) was presented an exceptional higher drug result in different pH medium.</p><p><strong>Conclusion: </strong>It was observed that CS/MMT was decreasing less drug release rate compared to f-GE-g-(CS/MMT-PANI). So that it can be clearly understood that f-GE-g-(CS/MMT-PANI) grafted nanocomposites have enhanced drug release activity in different pH medium.</p> ER -