TY - JOUR AU - TJANDRAWINATA, RAYMOND R. AU - HIENDRAWAN, STEVANUS AU - VERIANSYAH, BAMBANG PY - 2019/09/07 Y2 - 2024/03/28 TI - PROCESSING PARACETAMOL-5-NITROISOPHTHALIC ACID COCRYSTAL USING SUPERCRITICAL CO2 AS AN ANTI-SOLVENT JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 5 SE - Original Article(s) DO - 10.22159/ijap.2019v11i5.34554 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/34554 SP - 194-199 AB - <p><strong>Objective</strong><strong>:</strong> A new method of cocrystallization based on the use of supercritical carbon dioxide (CO<sub>2</sub>) as an anti-solvent was explored. In the present study, we investigate and analyze paracetamol (PCA)-5-nitroisophthalic acid (5NIP) cocrystal produced using supercritical anti-solvent (SAS) process.</p><p><strong>Methods: </strong>PCA-5NIP cocrystals prepared by SAS cocrystallization were compared to those produced using traditional solvent evaporation by rapid evaporation (RE) process. The cocrystals produced were characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), polarized light microscopy (PLM), Fourier Transform Infrared (FTIR) spectroscopy, particle size analysis and scanning electron microscopy (SEM).</p><p><strong>Results: </strong>The products obtained from SAS and RE process exhibited identical PXRD spectra and were distinguishable from the individual compounds, indicating the formation of a new phase. DSC analysis revealed that PCA-5NIP cocrystals from each method possess similar melting point which lies between the melting points of the parent compounds. Cocrystal particles with a mean diameter of 4.66 µm were produced from SAS process, which was smaller than those produced by traditional solvent evaporation method with a mean diameter of 38.09 μm.</p><p><strong>Conclusion: </strong>This study demonstrates the ability of SAS process to produce the submicron size of PCA-5NIP cocrystal with altered physicochemical properties in a single step process. </p> ER -