TY - JOUR AU - RAO, K. V. S. KOTESWARA AU - NADH, R. VENKATA AU - RATNAM, K. VENKATA PY - 2019/09/07 Y2 - 2024/03/29 TI - PERIODATE OXIDATION OF PEG–600, AN ESSENTIAL PHARMACEUTICAL POLYMER JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 11 IS - 5 SE - Original Article(s) DO - 10.22159/ijap.2019v11i5.34591 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/34591 SP - 251-256 AB - <p><strong>Objective: </strong>To study the kinetics of periodate oxidation of polyethylene glycol-600 (PEG-600), a familiar non-toxic polymer used in pharmaceutical and other fields of industry.</p><p><strong>Methods: </strong>Reactions were carried out in alkaline medium and measured the kinetics by iodometry. One oxygen atom loss or two electrons transfer was observed per each molecule of periodate i.e., the rate of reaction was measured periodate converts to iodate because the formed iodate species is unable to oxidize the substrate molecules.</p><p><strong>Results: </strong>Based on log (a-x) versus t plots, order w. r. t. oxidant (periodate) is unity. Reactions were found to be independent of substrate (PEG-600) concentration. A decrease in rate with an increase in alkali concentration [OH<sup>–</sup>] was found and order was inverse fractional. Temperature dependence of reaction rate was studied and then calculated the corresponding Arrhenius parameters.</p><p><strong>Conclusion: </strong>An appropriate rate law was proposed by considering the above experimental results.</p> ER -