TY - JOUR AU - SURINI, SILVIA AU - NOVITASARI, DIAN AU - YANUAR, ARRY PY - 2020/03/23 Y2 - 2024/03/29 TI - DISSOLUTION ENHANCEMENT OF LANSOPRAZOLE USING COCRYSTALLIZATION JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2020.v12s1.FF046 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/37584 SP - 202-206 AB - <p><strong>Objective</strong>: Lansoprazole (LPZ) is a Biopharmaceutics Classification System Class II drug. It has low solubility and high permeability, so its rate of<br>dissolution is a rate-limiting step for drug absorption. This study aimed to improve the dissolution rate of LPZ by forming cocrystals, using nicotinamide<br>(NCT) as the conformer.<br><strong>Methods</strong>: Cocrystals of LPZ were produced using the solvent evaporation and solvent-drop grinding methods with a molar ratio of 1:1 and 1:2.<br>The cocrystals were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), and differential scanning<br>calorimetry (DSC). The solubility and dissolution of the LPZ cocrystals were examined in distilled water.<br><strong>Results</strong>: FTIR was used to confirm the formation of hydrogen bonds between LPZ and NCT. DSC and XRD studies showed the formation of crystals<br>from cocrystals and a decrease of the melting point of the cocrystals. The dissolution study revealed that the cocrystals could increase the LPZ<br>dissolution rate by up to 8.4-fold compared with pure LPZ.<br><strong>Conclusion</strong>: LPZ cocrystal formation with NCT was successful in increasing the dissolution rate of LPZ.</p> ER -