TY - JOUR AU - NURFITRIYANA, NURFITRIYANA AU - HARMITA, HARMITA AU - ISKANDARSYAH, ISKANDARSYAH PY - 2020/03/23 Y2 - 2024/03/29 TI - IN VITRO STUDY OF A TRANSFERSOMAL GEL PREPARATION CONTAINING LYNESTRENOL AS A TRANSDERMAL DRUG DELIVERY SYSTEM JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 12 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2020.v12s1.FF052 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/37591 SP - 242-244 AB - <p><strong>Objective</strong>: Lynestrenol, a progestin hormone derivative, can suppress the productions of endogenous estrogen and progesterone hormones (ovaries)<br>to prevent ovulation. In this study, lynestrenol was included in various transfersomal gel preparations for its transdermal delivery into fat (F)-and<br>non-fat (NF)-containing skin tissues.<br><strong>Methods</strong>: Lynestrenol transfersome vesicles were prepared by encapsulating the drug in varied concentrations of phosphatidylcholine and Tween<br>80 using lipid film hydration method. Transfersomes were produced in the form of gel preparations at a dose of 0.15 mg/week and evaluated for<br>their particle size, percentage of entrapment efficiency, and particle polydispersity. We performed in vitro evaluations of the formulation variants F0<br>(lynestrenol gel control) and F1 and F2 (lynestrenol transfersome gels) with variations in their phosphatidylcholine and Tween 80 content. We then<br>performed an in vitro evaluation using the Franz diffusion cell (FDC) method for 12 h using all three formulations on F and NF-containing rat skin.<br><strong>Results</strong>: The FDC results demonstrated that lynestrenol was deposited into fat tissue and increased concentrations of Tween 80 (edge activator)<br>increased lynestrenol delivery into this tissue. In addition, the percentages of drug penetration from NF rat skin treated with F0, F1, and F2 gels were<br>19.56%, 20.13%, and 20.56%, respectively, and those from F rat skin were 17.16%, 17.38%, and 17.50%, respectively.<br><strong>Conclusion</strong>: In vitro evaluation using the FDC method indicates that transdermal drug delivery through to fat tissues using transfersomes is a<br>promising method for lynestrenol delivery.</p> ER -