TY - JOUR AU - PRATAMI, DIAH KARTIKA AU - RAHMAT, DENI AU - AMALIA, RIZKA NOOR AU - HERMASNYAH, HERI AU - GOZAN, MISRI AU - SAHLAN, MUHAMAD PY - 2022/02/15 Y2 - 2024/03/29 TI - FORMULATION AND DETERMINATION OF QUALITY PARAMETERS OF PROPOLIS EXTRACT MICROCAPSULE TABLETS FROM TETRAGONULA SAPIENS JF - International Journal of Applied Pharmaceutics JA - Int J App Pharm VL - 14 IS - 1 SE - Original Article(s) DO - 10.22159/ijap.2022.v14s1.10 UR - https://journals.innovareacademics.in/index.php/ijap/article/view/44430 SP - 47-52 AB - <p><strong>Objective</strong><strong>:</strong> The study aimed to develop the dry powder of propolis microcapsules into tablet preparations.</p><p><strong>Methods: </strong>The tablet preparation was developed by direct compression method using Avicel PH 102 (filler-binder-disintegrant) with variations in Avicel PH 102 concentration of 50%, 75%, and 100%, respectively. Each of the tablets from these formulations was determined by the quality parameters of the preparation.</p><p><strong>Results: </strong>The results showed that the dry powder microcapsules had a yellow-brown powder physical form, flow time of 0.413g/second, compressibility of 18.56%, and fine powder was 80.04%. Out of the three formulae produced, formula III was the best with a tablet diameter of 11.11±0.01 mm, the thickness of 5.26±0.03 mm, disintegration time of 9.40±0.14 min, hardness of 15.46±0.84 kg/cm<sup>2</sup>, weight uniformity of 506.74±2.86 mg, friability of 0.28±0.03%. Meanwhile, Pb and Cd metal contamination were not detected, microbial contamination with Total Plate Number gave (ALT) 4.20 x 10<sup>2</sup> colonies/g, Yeast Mold Number 1.18 x 10<sup>2</sup> colonies/g, and the water content of the tablet was 5.75%. The evaluation results also showed that formula III with a 100% Avicel PH 102 concentration had a relatively better disintegration time than others.</p><p><strong>Conclusion: </strong>Propolis extract microcapsule tablet has been success developed. The best formula was used 100% Avicel PH 102 concentration.</p> ER -