• Smita S. Aher Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India
  • Sagar T. Malsane Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India
  • R. B. Saudagar Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India



Nanosuspension, Solubility enhancement, Particle size, Surfactant, Colloidal dispersion, Oral bioavailability


Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in theOcular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.


Download data is not yet available.


Lenhardt T, Vergnault G, Grenier P, Scherer D, Langguth P. Evaluation of nanosuspension for absorption enhancement of poorly soluble drugs: in-vitro transport studies across intestinal epithelial monolayers. AAPS J 2008;10:435-8.

Arunkumar N, Deecarman M, Rani C. Nanosuspension technology and its application in drug delivery. Asian J Pharm 2009;3:168-73.

Xiaohui Pu, Jin Sun, Mol Li, Zhonggui He. Formulation of nanosuspensions as a new approach for the delivery of poorly, current nanoscience. Bentham Sci Publishers Ltd 2009;5:417-27.

Liversidge GG, Cundy KC. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: absolute oral bioavailability of nano-crystalline danazoline beagle dog. Int J Pharm 1995;125:91-7.

Shid RL, Dhole SN, Kulkarni N, Shid SL. Nanosuspension: a review. Int J Pharm Sci Rev Res 2013;22:98-106.

Senthil Kumar C, VedhaHari BN, Sharavanan SP, Subramanian N, Punitha S, Senthil Kumar V. Novel metronidazole nanosuspension as a controlled drug delivery system for anthelmintic activity. J Pharm Res 2010;3:2404-7.

Muller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in drug therapy. Rationale for development and what we can expect for the future. Adv Drug Delivery Rev 2001;47:3-19.

Kreuter K. Peroral administration of nanoparticles. Adv Drug Delivery Rev 1991;7:71-86.

Kavitha VB, Neethu CS, Dineshkumar B, Krishnakumar K, Anish John. Nanosuspension formulation: an improved drug delivery system. Nanoscience and Nanotechnology: An International Journal 2014;4:1-5.

Shid RL, Dhole SN, Kulkarni N, Shid SL. Nanosuspension: a review. Int J Pharm Sci Rev 2013;22:98-106.

Vaneerdenbrugh B, Vandenmooter G, Augustijns P. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm 2008;364:64–75.

Mounica Velmula, Prathibha Pavuluri, S Rajashekar, V Uma Maheswara Rao. Nanosuspension technology for poorly soluble drugs-a review. World J Pharm Pharm Sci 2015;4;1612-25.

Peters K, Leitzke S, Diederichs JE, Borner K, Hahn H, Moller RH. Preparation of clofazimine nanosuspensions for intravenous use and evaluation of its therapeutic efficacy in murine mycobacterium avium infection. J Antimicrobe Chemother 2000;45:77-83.

Jacobs C, Kayder O, Muller RH. Nanosuspension as a new approach for the formulation of poorly soluble drug tarazepide. Int J Pharma 2000,196:161-4.

Kayser O. Nanosuspension for the formulation of aphidicolin to improve drug targeting effects against Leishmania infected macrophages. Int J Pharma 2000;196:253-6.

Ponchel G, Montisci MJ, Dembri A, Durrer C, Duchkne D. Mucoadhesion of colloidal particulate systems in the gastrointestinal tract. Eur J Pharm Biopharm 1997;44:25-31.

Chen Y, Liu J, Yang X, Zhao X, Xu H. Oleanolic acid suspension: preparation, in vitro characterization and enhanced hepato-protective effect. J Pharma Pharmacol 2005;57:259-64.

Arunkumar N, Deecaraman M, Rini C. Nano-suspension-technology and its applications in drug delivery. Asian J Pharm 2009;3:168-73.



How to Cite

Aher, S. S., S. T. Malsane, and R. B. Saudagar. “NANOSUSPENSION: AN OVERVIEW”. International Journal of Current Pharmaceutical Research, vol. 9, no. 3, May 2017, pp. 19-23, doi:10.22159/ijcpr.2017.v9i3.19584.



Review Article(s)

Most read articles by the same author(s)