EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ALLIUM CEPA AERIAL LEAVES
DOI:
https://doi.org/10.22159/ijcpr.2017v9i6.23424Keywords:
Allium cepa aerial leaves, Cardio protection, IsoproterenolAbstract
Objective: The present work deals with the study of the ethanolic extract of fruits of Allium cepa aerial leaves for cardioprotective activity.
Methods: Cardioprotective activity of the ethanolic extract of aerial leaves of Allium cepa was determined by the administration of isoproterenol (60 mg/kg, s. c) for two days.
Results: Pretreatment with ethanolic extract of Allium cepa aerial leaves (200 mg/kg, p. o and 100 mg/kg, p. o) for 28 d in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have showed infiltration of inflammatory cells and lacking of continuity in muscle fiber was suggesting an irreversible cell injury.
Conclusion: Animals treated with ethanolic extract of Allium cepa aerial leaves showed less degenerative changes compared to isoproterenol-treated animals.Downloads
References
Boudina S, Laclau MN, Tariosse L. Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. Am J Physiol: Heart Circ Physiol 2003;282:H821–31.
Burton KP, McCord JM, Ghai G. Myocardial alteration due to free radical generation. Am J Physiol 1984;84:H776–83.
Rona G, Chappel CI, Balazs T, Gaudry R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch Pathol 1959;76:443–5.
Renu Gupta, Bandana Thakur, Pushpendra Singh, HB Singh. Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates. Indian J Med Res 2010;131:809-13.
Ebrahimi H, Bazargani A, Pourshahidi S, Rafiee A. Assessment of antimicrobial activity of onion extract (Allium cepa) on Streptococcus mutans and Streptococcus sanguinis; in vitro study. Adv Nat Appl Sci 2012;6:1609-13.
Ozougwu, Jevas C. Anti-diabetic effects of Allium cepa (onions) aqueous extracts on alloxan-induced diabetic Rattus novergicus. J Med Plants Res 2011;5:1134-9.
CK Kokate, AP Purohit, SP Gokhale. Methods of Glycosides, Flavonoids and Alkaloids: Pharmacognosy Volume I and II 4th Edition; 2013. p. 168-82.
OECD guidelines for the testing of chemicals (Acute oral toxicity up and down procedure); 2008.
Koneri R, Balaraman R, Hariprasad, Vinoth Kumar M, Ali A. Cardioprotective effect of Momordica cymbalaria fenzl in rats with isoproterenol induced myocardial injury. J Clin Diagn Res 2008;2:699-705.
Baroldi G. Myocardial necrosis: the need for definition. J Mol Cell Cardiol 1974;6:401–2.
Kareem MA, Krushna GS, Hussain SA, Dev KL. Effect of aqueous extract of nutmeg on hyperglycaemia, hyperlipidaemia and cardiac histology associated with isoproterenol-induced myocardial infarction in rats. Trop J Pharm Res 2009;8:337-44.
Sabeena Farvin KH, Anandan R, Hari Senthil KS, Shiny KS. Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats. J Med Food 2006;9:531-6.
Suchalata S, Shyamala Devi CS. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Indian J Exp Biol 2004;42:174–8.
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