A PROSPECTIVE STUDY OF DRUG UTILIZATION PATTERN OF ANTI-EPILEPTIC DRUGS AND THEIR ADVERSE EFFECTS IN A TERTIARY CARE HOSPITAL

Henry Daniel Raj  T.; Sylvia A.; Chidambaranathan S.; Nirmala P.

doi:10.22159/ijcpr.2017v9i6.23427

Authors

Henry Daniel Raj T. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
Sylvia A. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
Chidambaranathan S. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India
Nirmala P. Post Graduate, Department of Pharmacology, Raja Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India

DOI:

https://doi.org/10.22159/ijcpr.2017v9i6.23427

Keywords:

Drug utilization study (DUS), Anti-Epileptic Drugs (AEDs), Adverse Reactions (AR), Seizure disorder

Abstract

Objective: Epilepsy or seizure disorder is a common neurologic disorder in the pediatric age group and occurs with a frequency of 4-6 cases per thousand children. Epilepsy, particularly childhood epilepsy, remains a challenge to treat. The management of epilepsy is primarily based on theuse of anti-epileptic drugs. Surgery and diet therapy are the other modes of treating childhood seizures. To get an insight into the utilization pattern of anti-epileptic drugs (AEDs) used in pediatric seizures.

Methods: This prospective, longitudinal study was conducted for a period of 8months in Paediatric Neurology Department of a tertiary care teaching hospital. The data collected from 50 children at the end of the study, were compiled in a specially designed data form and were analyzed.

Results: The distribution of paediatric seizures was found to be high in male children (62%) and in the age group of 2 to 5 y (46%). The majority of the children (70%) were diagnosed with Generalized Tonic-clonic seizures. Sodium valproate was the commonly prescribed AED in all forms of seizures followed by Carbamazepine (18%), Phenobarbitone (4%) and Phenytoin Sodium (4%). AEDs were mostly prescribed as monotherapy (82%). Adverse reactions noted during this study was minimal (12%).

Conclusion: Sodium valproate, a conventional AED still remains the commonly prescribed AED for all types of seizures in children aged 2 to 16 y and also was found to be effective and safe.

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