EVALUATION OF DRUG-DRUG INTERACTIONS IN PATIENTS OF GENERAL MEDICINE, ICU and EMERGENCY DEPARTMENTS AT A TERTIARY CARE HOSPITAL
DOI:
https://doi.org/10.22159/ijcpr.2018v10i3.27345Keywords:
Drug-drug interaction, Significant, Minor, Serious interactionsAbstract
Objective: To evaluate the drug-drug interactions in General medicine, ICU and Emergency departments.
Methods: It is a prospective-observational study. This study included hospital In-patients treated in General medicine, ICU and Emergency. Data were collected from the medical records of In-patients which includes patient's demographic details, medical history, social history, treatment chart, status and drug-drug interaction is assessed by using Lexicompand Medscape and other tertiary resources and documented in a suitably designed data collection form.
Results: A total of 250 subjects were enrolled in the study. The majority (23.6%) of cases were identified in the age group 51–60 y old. Higher rate of DDIs was identified in the male gender prescriptions. 70% moderate interactions, 33.6% Minor interactions, 6.4% serious interaction found in General medicine, ICU and Emergency departments.
Conclusion: Polypharmacy, age and comorbid condition were took part major role in drug-drug interactions.
Downloads
References
Sheldon H, Preskorn, David F. Guide to psychiatric drug interactions; 2006;13:35-64.
Glintborg B, Andersen SE, Dalhoff K. Drug-drug interactions among recently hospitalized patients-frequent but mostly clinically insignificant. Eur J Clin Pharmacol 2005;61:675–81.
Souza JMC, Thomson JC. Prevalence of potential drug-drug interactions and its associated factors in a Brazilian teaching hospital. J Pharm Pharm Sci 2006;9:427–33.
Nazariab AM, Moqhadam KN. Evaluation of pharmacokinetic drug interactions in prescriptions of intensive care unit (ICU) in a teaching hospital. Int J Pharmacol Res 2006;3:215-8.
Rafi SM, Naqvi SBS, Khan UM. Evaluation of potential drug-drug interactions with antidepressants in two tertiary care hospitals. J Clin Diagnostic Res 2015;9:FC05-FC08.
Barot AP, Malhotra DS, Patel JP. Evaluation of potential drug-drug interactions in patients of the emergency medicine department at a tertiary care teaching hospital: a prospective study. Int Study Sci Study 2015;3:48-53.
Soherwardi S, Chogtu B, Faizal P. Surveilance of the potential drug-drug interactions in the medicine department of a tertiary care hospital. J Clin Diagnostic Res 2012;6:1258-61.
Published
How to Cite
Issue
Section
