IN VITRO HEPATOPROTECTIVE ACTIVITY OF YELLOW LEAF EXTRACTS OF THESPESIA POPULNEA AGAINST CARBON TETRACHLORIDE INDUCED TOXICITY

UMADEVI A.; P. AJITH KUMAR

doi:10.22159/ijcpr.2019v11i3.34087

Authors

UMADEVI A. Department of Pharmacognosy, Malik Deenar College of Pharmacy, Kasaragod, Kerala, India
P. AJITH KUMAR Department of Pharmacognosy, Malik Deenar College of Pharmacy, Kasaragod, Kerala, India

DOI:

https://doi.org/10.22159/ijcpr.2019v11i3.34087

Keywords:

Thespesiapopulnea, Methanolic extract, Hepatoprotective activity

Abstract

Objective: The study was aimed to evaluate in vitro hepatoprotective activity of yellow leaf extracts of Thespesiapopulnea.

Methods: Hepatoprotective activity is studied by carbon tetrachloride-induced hepato-toxicity in isolated rat hepatocytes. The biochemical parameters observed in serum were serum glutamate oxaloacetate transaminase (SGOT/AST), serum glutamate pyruvate transaminase (SGPT/ALT) levels. The extracts exhibited a dose-dependent reduction in AST, ALT levels.

Results: Methanolic extract was found to exhibit higher hepatoprotection. T. populnea extract was found to be antihepatotoxic at a concentration of 125 mcg with a significant decrease in ALT (P<0.001) and AST (P<0.0001).

Conclusion: The results suggest that the methanolic extract has produced significant (p<0.001) hepatoprotection by decreasing the activity of serum enzymes which is comparable to that of standard drug silymarin.

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