@article{KHARE_KISHORE_SHARMA_2022, title={ACUTE ORAL TOXICITY OF BAUHINIA VARIEGATA AND MADHUCA LONGIFOLIA IN MICE}, volume={14}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/44660}, DOI={10.22159/ijcpr.2022v14i2.1966}, abstractNote={<p><strong>Objective: </strong><em>Bauhinia variegata </em>and <em>Madhuca longifolia</em>, which belongs to Leguminosae and Sapotaceae, respectively, is traditionally used in India for the cure of many diseases. This study represents the result of acute oral toxicity of <em>Bauhinia variegata </em>and <em>Madhuca longifolia</em> on swiss albino mice.</p> <p><strong>Methods: </strong>Following acute oral administration of 2500 mg/kg crude extracts of <em>Bauhinia variegata </em>and <em>Madhuca longifolia</em> to swiss albino mice, no mortalities or evidence of adverse effects were observed.</p> <p><strong>Results: </strong>The results of this study agree with those of <em>in vitro</em> experiments, indicating that the use of <em>Bauhinia variegata </em>and <em>Madhuca longifolia</em> leaves is scientifically validated.</p> <p><strong>Conclusion: </strong>The result was in agreement with that of <em>in vitro</em> experiments, whereby the crude extracts of <em>Bauhinia variegata</em> and <em>Madhuca longifolia</em> did not show toxicity. Based on the outcome of acute toxicity in experimental mice, the crude extracts of both <em>Bauhinia variegata</em> and <em>Madhuca longifolia</em> could be regarded as safe in experimental mice. Further toxicity study over a longer period of time involving detection of effects on vital organ functions would ensure that the plants are safe for human consumption.</p>}, number={2}, journal={International Journal of Current Pharmaceutical Research}, author={KHARE, PRAGATI and KISHORE, KAMAL and SHARMA, DINESH KUMAR}, year={2022}, month={Mar.}, pages={69–71} }