ANTIOBESITY EFFECT OF ETHANOL EXTRACT OF ANREDERA CORDIFOLIA (TEN.) STEENIS LEAVES ON OBESE MALE WISTAR RATS INDUCED BY HIGH_CARBOHYDRATE DIET
Objective: Overweight or obesity is one of the health problems that can promote cardiovascular risk diseases such as hypertension, hyperlipidemia, atherosclerosis, and diabetes mellitus. Anredera cordifolia (Ten.) Steen is leaves have been used traditionally to reduce body weight. In this study, the anti obesity effect of ethanol extract of A. cordifolia leaves was tested on obese rats induced by high-carbohydrate diet.
Methods: Animal were divided into five groups consisted of the negative control group, positive control group, an ethanol extract of A. cordifolia leaves at doses of 50 and 100 mg/kg bw group, and Orlistat group at a dose of 21.6 mg/kg bw. High-carbohydrate diet was given ad libitum for 30 d to all mice in groups, except to the negative control group. Then the rats were treated based on their groups for 14 d, and the high-carbohydrate diet was still given during the treatment. The parameters observed were the increment of body weight, food index, and feces index.
Results: The results showed that ethanol extract of A. cordifolia leaves at a dose of 100 mg/kg bw had the lowest increment of body weight (59.97Â±5.63) among other groups, and it was significantly different compared to the positive control group (76.11Â±8.50). The percentage of the food index and feces index did not differ significantly among all test groups.
Conclusion: Ethanol extract of A. cordifolia leaves at a dose of 100 mg/kg bw has a potency of the antiobesity agent by inhibiting the increment of the body weight of obese rats induced by high-carbohydrate diet, without affecting their appetite and bowel movement.
Keywords: Obesity, High-carbohydrate diet, Antiobesity, Anredera cordifolia (Ten.) Steenis
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