• Sachinkumar R. Patil
  • Rahul Shivaji Patil Department of Microbiology and 3Department of Chemistry, Dr. Ghali College, Gadhinglaj-416502 (M.S.), India
  • A. G. Godghate


Objective: There is an immense need to develop an alternative antimicrobial source for the treatment of several infectious diseases and restrict its vectors. So, evaluation of phytochemicals from Mentha piperita, its antibacterial and adulticidal potential was undertaken in the present study.

Methods: The organic solvent of ethanol and water were used for the preparation of extract for the study. These extracts were analyzed for the qualitative and quantitative phytochemicals. Antimicrobial activity was determined by using agar well diffusion method, and Bioassay was carried out by "Sugar Bait" Method to check adulticidal potential.

Results: The Mentha piperita were found a rich source of phytochemical compounds like diterpenes, steroids, tannin, flavonoids, cardial glycosides, alkaloids, phenols, coumarin, and saponin. Both the extracts possesses active antibacterial compounds which shown antibacterial activity. The aqueous (5% of 50 µl) and ethanolic (5% of 100 µl) extract (EA) were found as effective concentration. Salmonella typhimurium showed resistance against both the extracts. The aqueous extract (AE) has found with effective adulticidal potential. Hence it can be used to control and repel most popular disease spreading Dipterian vector, Musca domestica.

Conclusion: These results confirm the presence of antibacterial, adulticidal compounds in Mentha piperita which gives an opportunity to explore the possible usage of Mentha piperita in the development of antibiotics and insecticides.

Keywords: Mentha piperita L., Phytochemical analysis, Antibacterial, Adulticidal potential


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Kirethekar Basu I. Indian Medicinal Plants; 1985. p. 714-6.

Clark RK, Menory RC. Environmental effects or peppermint (Mentha piperita). Aust J Plant Physiol 1980;7:685-92.

Basheer A Al-Sum, Abdullah A Al-Arfaj. Antimicrobial activity of the aqueous extract of mint plant. Sci J Clin Med 2013;2:110-3.

Tumah H. Fourth-generation cephalosporins: in vitro activity against nosocomial Gram-negative bacilli compared with beta-lactam antibiotics and ciprofloxacin. Chemotherapy 2005;51:80-5.

Derrida M. What is bitter melon (Momordica charantia)?; 2003. Available from: business/ messages/ 40688.html. [Last accessed on 10 Nov 2015].

Thongson C, Davidson PM, Mahakarnchanakul W, Weiss J. Antimicrobial activity of ultrasound-assisted solvent-extracted spices. Lett Appl Microbiol 2004;39:401-6.

Adam KA, Sivropoulou SK, T Lanaras, M Arsenakis. Antifungal activities of Origanum vulgare subsp. hirtum, Mentha spicata, Lavandula angustifolia and Salvia fruticosa essential oils against human pathogenic fungi. J Agric Food Chem 1998;46:1739-45.

Godghate A, Sawant R, Sutar A. Phytochemical analysis of ethanolic extract of roots of Carrisa Carandus Linn. Rasayan J Chem 2012;5:456-9.

Patil RS, Godghate AG, Sawant RS. Phytochemicals and antimicrobial activity of leaves of Homonoia riparia L. Int J Pharm Biol Sci 2014;5:352-6.

Patil RS, Bhise KK. Evaluation of phytochemicals and in vitro antimicrobial activity of aqueous and ethanolic extract from seeds of Ricinus communis Linn. Eur J Biotechnol Biosci 2015;3:19-23.

Patil RS, Harale PM, Shivangekar KV, Kumbhar PP, Desai RR. Phytochemical potential and in vitro antimicrobial activity of Piper betle Linn. leaf extracts. J Chem Pharm Res 2015;7:1095-101.

Patil RS, Desai AB, Wagh SA. Comparative study of antimicrobial compounds extracted from leaves of Nicotiana Tabacum and cigarette. World J Pharm Pharm Sci 2015;4:1511-8.

Sawicki RM. Some general considerations of housefly rearing techniques. Bull WHO 1964;31:535-7.

Freedman B, Nowak LJ, Kwalek WF, Berry EC, Gutnrie WD. A bioassay for plant derived pest control agents using the European corn borer. J Econ Entomol 1979;72:541–5.

Mansour SA, Reda FA, Bakr LS, Hamouda RIM. The adulticidal activity of some botanical extracts, commercial insecticides, and their binary mixtures against the housefly, Musca domestica L. Egyptian Academic J Biol Sci 2012;5:151-67.

Harborne JB, Willians CA. Advances in flavonoid research since 1992. Phytochem Oxford 2000;55:481-504.

Baez DA, Vallejo LGZ, Jimenez-Estrada M. Phytochemical studies on Senna skinneri and Senna wishizeni. Nat Prod Lett Berks 1999;13:223-8.

Ogundipe OO, Moody JO, Houghton PJ, Odelola HA. Bioactive chemical constituents from Alchormea laxiflora (benth) pax and hoffman. J Ethnopharmacol Lausanne 2001;74:275-80.

Xu HX, Lee SF. The activity of plant flavonoids against antibiotic-resistant bacteria. Phytother Res London 2001;15:39-43.

Chattopadhyay D, Maiti K, Kundu AP, Chakraborty MS, Bhadra R, Maudal SC, et al. Antimicrobial activity of Alstonia macrophylla: A folklore of bay islands. J Ethnopharmacol Lausanne 2001;77:49-55.

Harborne JB. Photochemical methods: a guide to modern techniques of plant analysis. Chapman and Hall London; 1973. p. 279.

Lin LU, Shu-wen L, Shi-bo J, Shu-guang W. Tannin inhibits HIV-1 entry by targeting gp41. Acta Pharmacol Sin 2004;25:213-8.

Akiyama H, Kazuyasu F, Yamasaki O, Oono T, Iwatsuki K. Antibacterial action of several tannins against Staphylococcus aureus. J Antimicrobial Chemother 2001;48:487-91.

Funatogawa K. Antibacterial activity of hydrolysable tannins derived from medicinal plants against Helicobacter pylori. Microbiol Immunol 2004;48:251-61.

Hérouart D, Sangwan RS, Fliniaux MA, Sangwan-Norreel BS. Variations in the leaf alkaloid content of androgenic diploid plants of Datura innoxia. Planta Med 1988;54:14-7.

Mahato SB, Sen S. Advances in triterpenoid research, 1990-1994. Phytochemistry 1997;44:1185-236.



How to Cite

Patil, S. R., R. S. Patil, and A. G. Godghate. “MENTHA PIPERITA LINN: PHYTOCHEMICAL, ANTIBACTERIAL AND DIPTERIAN ADULTICIDAL APPROACH”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 3, Mar. 2016, pp. 352-5,



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