FORMULATION AND IN VITRO EVALUATION OF ORLISTAT ORODISPERSIBLE TABLETS FOR ENHANCEMENT OF DISSOLUTION RATE

Authors

  • Kambham Venkateswarlu Faculty of Pharmacy, Department of Pharmaceutics, Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515001, Andhra Pradesh, India
  • S.b. Thirumalesh Naik
  • K. B. Chandrasekhar

Keywords:

Direct compression, Melt granulation method, Orlistat, Orodispersible tablets, Polyethylene glycol

Abstract

Objective: The aim of the present study was to formulate the oro dispersible tablets (ODTs) of Orlistat (OST) by direct compression technique using melt granulation method.

Methods: Super disintegrants were used for the preparation of ODTs namely Crospovidone (CP), Croscarmellose sodium (CCS), Sodium starch glycolate (SSG). The powder mixture was subjected to pre compression evaluation like FTIR, Micromeritic, solubility studies and post-compression evaluation like friability, hardness, wetting time, dispersion time, disintegration time and in vitro dissolution rate.

Results: FTIR studies confirmed that there was no chemical interaction between the drug and excipients. Micromeritic studies revealed that the powder blend has good flow ability. The results of hardness and friability complied with the official standards. The solid dispersions (SDs) prepared in OST to PEG 6000 ratio of 1:2 were showed good solubility than other SDs and it was selected for formulation development. It was evident from the results that the increase in super disintegrants concentration decreases the wetting, dispersion and disintegration times and CP showed the best results than other super disintegrating agents.

Conclusion: The F4 formulation showed optimum drug release of 98.99 % at the end of 15 min when compared to the other formulations; it might be due to the presence of CP.

Keywords: Direct compression, Melt granulation method, Orlistat, Orodispersible tablets, Polyethylene glycol. 

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Published

01-04-2016

How to Cite

Venkateswarlu, K., S. T. Naik, and K. B. Chandrasekhar. “FORMULATION AND IN VITRO EVALUATION OF ORLISTAT ORODISPERSIBLE TABLETS FOR ENHANCEMENT OF DISSOLUTION RATE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 4, Apr. 2016, pp. 236-41, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/10857.

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