DECREASE OF LIVER FUNCTION AFTER TREATMENT OF ANTITUBERCULOSIS DRUGS IN TUBERCULOSIS PATIENTS WITH MALNUTRITION AND ALCOHOL CONSUMPTION
Keywords:
ATD-FDC-malnutrition-alcohol consumptionAbstract
Objective: To evaluate the decrease of liver function after treatment of antituberculosis drugs-fixed doses combination (ATD-FDC) category 1 in tuberculosis patients with malnutrition and alcohol consumption.
Methods: This was an experimental study, with a quasi-experimental pretest and posttest design, to evaluate the increase in SGPT in pulmonary TB patients with malnutrition, treated with ATD-FDC for 8 w. Inclusion criteria were: pulmonary TB patients, aged ≥ 18 y old, who would receive ATD-FDC category 1 treatment, did not have an increase in SGPT level at the beginning of the treatment and were willing to join the study. This study was conducted in all community health centers in Kupang, Indonesia.
Results: The result of this study showed that percentage of SGPT level is increased after treatment of ATD-FDC compared with before treatment in TB patient with malnutrition compared with TB patients without malnutrition (135.1% vs. 54.7%; p<0.001). The difference of SGPT level in TB patients ≥40 y versus<40 y was 15.5 IU/l versus 9.1 IU/l (p<0.05). The difference of SGPT level in TB patient ≥40 y with routine alcohol consumption habit compared with non-routine alcohol consumption was 29.3 IU/l vs. 12.8 IU/l (p<0.01).
Conclusion: Pulmonary TB patients with malnutrition had a larger decrease in liver function after treatment with ATD-FDC category 1 for 8 w, compared to those without malnutrition. Routine alcohol consumption had an effect on the increase in SGPT level in older patients.
Keywords: ATD-FDC-malnutrition-alcohol consumption.
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