SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF 2, 3-ARYL SUBSTITUTED 1, 3-BENZOXAZIN-4-ONE DERIVATIVES

Authors

  • Ajit Kandale Manipal College of Pharmaceutical Sciences, Manipal 576104, India
  • Renu Ohlyan Maharishi Markandeshwar College of Pharmacy, Mullana, Ambala, Haryana, India.
  • Ganesh Kumar Manipal College of Pharmaceutical Sciences, Manipal 576104, India.

Keywords:

1, 3-benzoxazin-4-one, Antiproliferative activity, MCF-7 cell lines, Molecular docking

Abstract

Objective: The aim of the present work was to design and synthesize 2, 3-aryl substituted 1, 3-benzoxazin-4-one derivatives and evaluate them for in-vitro antiproliferative activity against human breast adeno-carcinoma cells.

Methods: The compounds were synthesized and screened for in-vitro antiproliferative activity against MCF-7 cell lines using 96 well plate method.

Results: 3 out of 9 synthesized compounds showed good in-vitro inhibition of MCF-7 cell lines. Compound 2 showed least IC50 (highest active) i.e. 0.89 µg followed by compound 4 (IC50= 1.02 µg) and compound 3 (IC50= 1.19 µg). 4 compounds showed more than 90 % inhibition at 100 µg after 48 h incubation.

Conclusion: This class of compounds showed some initial promising activity which can be further expanded by synthesizing and testing more analogs of this kind against MCF-7 cell lines which may give good leads to proceed.

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Author Biography

Ajit Kandale, Manipal College of Pharmaceutical Sciences, Manipal 576104, India

Ph.D Scholar

References

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Published

01-07-2014

How to Cite

Kandale, A., R. Ohlyan, and G. Kumar. “SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF 2, 3-ARYL SUBSTITUTED 1, 3-BENZOXAZIN-4-ONE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 68-71, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1198.

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