STUDIES ON DEVELOPMENT OF SUSTAINED RELEASE DILTIAZEM HYDROCHLORIDE MATRICES THROUGH JACKFRUIT MUCILAGE
Keywords:Diltiazem HCl (DLT), Jackfruit mucilage, Tamarind seeds, Matrics
Objective: The sustained release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release diltiazem hydrochloride matrix tablets using natural polymers and gums like jackfruit mucilage and tamarind polysaccharide.
Methods: Tablets were prepared by direct compression method and evaluated for various physical parameters. Direct compression method using response surface methodology, followed by optimization of the evaluation parameters were employed to get final optimized formulation.
Results: Among all formulations, M2 shows 92.87% better controlled release at the end of 12 hrs. The release co-efficient values â€˜n' (>0.5) indicated that the drug release followed non fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable.
Conclusion: Diltiazem HCl matrices could be developed with desirable release modulation for a once daily administration.
Gupta PK, Leung SH, Robinson JR. In:bioadhesive drug delivery systems. CRC Press, Boca Raton, Florida;1990. p. 65-92.
Ravi PR, Ganga S, Saha RN. Design and study of lamivudine oral controlled release tablets. J American Association of Pharm Scientists Pharm Sci Tech 2007;8 (4):1-9.
Prakash P, Porwal M, Saxena A. Role of natural polymers in sustained release drug delivery system:application and recent approaches. Int Res J of Pharmacy 2011;2(9):6-11.
Swarbrick J, Boylan JC. Optimization techniques in formulation and processing, Encyclopedia of Pharmaceutical technology. New York:Marcel Dekker;1994. p. 70.
Montgomery DC. Introduction to factorial deigns. Design and Analysis of Experiments. 5th ed. Wiley India Pvt. Ltd:New Delhi;2004. p. 170-217.
Schwartz BJ, Connor RE. Optimization technique in pharmaceutical formulations and processing. J Drugs and Pharm Sci in Modern Pharmaceutics 1996;72(3):727-54.
Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's the pharmacological basis of therapeutics. 11th Ed. McGraw-Hill medical publishing division;2006. p. 625-630.
Rao PS, Srivastava HC. Tamarind, in Whistler RL (edn), Industrial Gums, 2nd edn. Academic Press:New York;1973. p. 369-411.
Kumar P, Kulkarni GT. Characterization of mucilage from artocarpus heterophyllus as pharmaceutical excipient. J of Chronotherapy and Drug Delivery 2013;4(1):31-43.
Coates J. Interpretation of infrared spectra, a practical approach. John Wiley & Sons Ltd, Chichester, Meyers RA, editors. Encyclopedia of Analytical Chemistry;2000. p. 10815â€“837.
Cartensen JT. Drug stability:principle and practices, edited by Marcel Dakker, 2nd edn New York;1999. p. 538-550.