ESSENTIAL OILS ARE ENDORSED FOR HIGHER SOLUBILIZATION OF MANY AQUEOUS INSOLUBLE DRUGS

Authors

  • M. Joyce Nirmala Centre for Nanobiotechnology, VIT University, Vellore, India
  • Andrew Ebenazer Centre for Nanobiotechnology, VIT University, Vellore, India
  • Amitava Mukherjee Centre for Nanobiotechnology, VIT University, Vellore, India
  • N. Chandrasekaran Centre for Nanobiotechnology, VIT University, Vellore, India

Keywords:

Clove oil, Cinnamon oil, Solubility, Drugs

Abstract

Objectives: Our study focused on improving or enhancing the solubilization effect of many water insoluble drugs that are under the category BCS Class II-IV.

Methods: The solubility of ten such drugs was checked in clove and cinnamon oils, owing to their higher solubility capacity.

Results: Out of these drugs, carvedilol, followed by, ezetimibe and olmesartan showed good solubilization in both these oils.

Conclusion: These oils could thus be used in the development of drug delivery system for the above-mentioned drugs.

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References

Nirmala MJ, Mukherjee A, Chandrasekaran N. A unique nanoemulsion drug delivery system for azithromycin and its antibacterial activity. J Adv Sci Eng Med 2014;6(4):430-6.

Nirmala MJ, Mukherjee A, Chandrasekaran N. A distinctive drug delivery system focused on contemporary drugs. J Adv Sci Eng Med In press 2014;6:1-17.

Nirmala MJ, Saranya S, Mukherjee A, Chandrasekaran N, J. Enhancing the efficacy of azithromycin against bacterial strains using simple microemulsion technique. J Drug Deliv 2013;1(2):157-64.

Nirmala MJ, Mukherjee A, Chandrasekaran N, J. Enhanced solubilization of aqueous insoluble anti-hypertensive drug. J Int Pharm Sci 2012;4(5):366-8.

Nirmala MJ, Mukherjee A, Chandrasekaran N. Improved efficacy of fluconazole against candidiasis using bio-based microemulsion technique. J Biotechnol Appl Biochem 2013;60(4):417-29.

Published

01-07-2014

How to Cite

Nirmala, M. J., A. Ebenazer, A. Mukherjee, and N. Chandrasekaran. “ESSENTIAL OILS ARE ENDORSED FOR HIGHER SOLUBILIZATION OF MANY AQUEOUS INSOLUBLE DRUGS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 646-7, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1208.

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Short Communication(s)

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