ESSENTIAL OILS ARE ENDORSED FOR HIGHER SOLUBILIZATION OF MANY AQUEOUS INSOLUBLE DRUGS
Keywords:
Clove oil, Cinnamon oil, Solubility, DrugsAbstract
Objectives: Our study focused on improving or enhancing the solubilization effect of many water insoluble drugs that are under the category BCS Class II-IV.
Methods: The solubility of ten such drugs was checked in clove and cinnamon oils, owing to their higher solubility capacity.
Results: Out of these drugs, carvedilol, followed by, ezetimibe and olmesartan showed good solubilization in both these oils.
Conclusion: These oils could thus be used in the development of drug delivery system for the above-mentioned drugs.
Downloads
References
Nirmala MJ, Mukherjee A, Chandrasekaran N. A unique nanoemulsion drug delivery system for azithromycin and its antibacterial activity. J Adv Sci Eng Med 2014;6(4):430-6.
Nirmala MJ, Mukherjee A, Chandrasekaran N. A distinctive drug delivery system focused on contemporary drugs. J Adv Sci Eng Med In press 2014;6:1-17.
Nirmala MJ, Saranya S, Mukherjee A, Chandrasekaran N, J. Enhancing the efficacy of azithromycin against bacterial strains using simple microemulsion technique. J Drug Deliv 2013;1(2):157-64.
Nirmala MJ, Mukherjee A, Chandrasekaran N, J. Enhanced solubilization of aqueous insoluble anti-hypertensive drug. J Int Pharm Sci 2012;4(5):366-8.
Nirmala MJ, Mukherjee A, Chandrasekaran N. Improved efficacy of fluconazole against candidiasis using bio-based microemulsion technique. J Biotechnol Appl Biochem 2013;60(4):417-29.