SUPPLEMENTATION OF Α-LIPOIC ACID IN DIABETIC PERIPHERAL NEUROPATHY: A PROSPECTIVE OPEN LABEL RANDOMIZED CONTROLLED TRIAL
Keywords:Nil, Diabeticperipheral neuropathy, Nerveconduction, Glycaemiccontrol
Abstract Objective: Diabetic peripheral neuropathy is the most common long term complications associated with reduced nerve conduction and blood flow. The present study was designed to investigate the effect of oral supplementation of Î±-lipoic acid (600 mg/day) on peripheral, sensory and motor nerve conduction and glycaemic control in type 2 diabetes mellitus with peripheral neuropathy. Methods: A total of 20 patients were enrolled in this study, then randomly allocated to two groups control (n=10) and intervention group (n=10). Patients in control group received only oral hypoglycaemic treatment and in intervention group received Î±-lipoic acid (600 mg/day) oral supplementation along with their oral hypoglycaemic treatment for a period of 3 months. Nerve conduction and glycaemic control were measured at the base line and at the end of 3 months by using specific methods. Results: In intervention group Î±-lipoic acid supplementation significantly improves 6 of 15 electrophysiological parameters of nerve conduction. Distal latency of peroneal (mean Â± SD 5.13 Â± 0.52 vs 4.92Â±0.55; p<0.02), median (mean Â± SD 3.66 Â± 0.76 vs 3.53Â±0.63; p<0.03) & ulnar motor nerves (mean Â± SD 2.91 Â± 0.32 vs 2.82Â±0.36; p<0.01), and Nerve Conduction Velocity of peroneal (mean Â± SD 42.0 Â± 3.07 vs 43.4Â±2.13; p<0.03), median (mean Â± SD 51.4 Â± 3.31 vs 52.2Â±3.59; p<0.01) & ulnar motor nerves (mean Â± SD 51.0 Â± 5.84 vs 52.1Â±5.46; p<0.03) shows significant improvement. Conclusion: Oral supplementation of Î±-lipoic acid was found to be effective in improving motor nerve conduction of upper and lower extremities in patients with diabetic peripheral neuropathy.
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