• Y. Deepthi Priya Arya College of Pharmacy,Kandi,Sangareddy
  • Y. A. Chowdary NRI college of Pharmacy, Vijayawada.
  • T. E. G. K. MURTHY Bapatla college of Pharmacy, Bapatla.
  • B. Seshagiri Aurobindo Pharma Limited, Hyderabad


Atomoxetine HCl, MUPS, Bitter taste, Taste masking, HPMC, HPC, Methacrylate Copolymer, Eudragit EPO


Objective: Atomoxetine HCl is extremely bitter in taste and is available as capsule dosage forms in various markets. In order to improve the pediatric compliance, the present study was aimed to mask the bitter taste of Atomoxetine HCl.

Methods: Bitter taste of Atomoxetine HCl was masked by multi-unit particulate pellet coating (MUPS) technology using Fluid Bed Processor in two step process. Initially drug layering was done on microcrystalline cellulose pellets followed by Polymer coating on drug layered pellets as Taste masking layer.

Results: Good efficiency of drug layering was observed with the combination of HPMC (Hydroxypropyl methyl cellulose) and HPC (Hydroxypropyl cellulose) as binders. Drug layered pellets were coated with different concentrations of Methacrylate Copolymer as Taste masking polymer. The prepared taste masked pellets were evaluated for taste and drug content. From the In-vitro and In-vivo taste evaluation, bitter taste of Atomoxetine HCl was masked with 25 mg of Eudragit EPO.

Conclusion: Bitter taste of Atomoxetine HCl was masked using Eudragit EPO with multi-unit particulate pellet (MUPS) technology using Fluid Bed Processor.


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How to Cite

Deepthi Priya, Y., Y. A. Chowdary, T. E. G. K. MURTHY, and B. Seshagiri. “DESIGN AND EVALUATION OF ATOMOXETINE HCl PELLETS BY MUPS TECHNOLOGY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 110-5,



Original Article(s)