IN SILICO MOLECULAR DOCKING AND PHARMACOKINETIC PREDICTION OF GALLIC ACID DERIVATIVES AS PPAR-Î³ AGONISTS

Bhavesh C Variya; Siddharth J. Modi; Jignasa K. Savjani; Snehal S. Patel

doi:10.22159/ijpps.2017v9i1.15294

Authors

Bhavesh C Variya Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India
Siddharth J. Modi Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth deemed University, Pune, India
Jignasa K. Savjani Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India
Snehal S. Patel Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India

DOI:

https://doi.org/10.22159/ijpps.2017v9i1.15294

Keywords:

Diabetes, Gallic acid, In silico designing, Molecular docking, Nil

Abstract

Objective: To perform molecular docking and pharmacokinetic prediction of gallic acid derivatives as Peroxisome proliferator-activated receptors-Î³ (PPAR-Î³) agonist for the treatment of diabetes.

Methods: Molecular docking study on gallic acid and different derivatives of gallic acid was performed using GOLD v5.2 software. In addition to this, all the derivatives were analysed for drug likeliness, Lipinski's rule and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties using online tools like admet SAR, Molinspiration and Medchem designer.

Results: Molecular docking studies reveals that SSP-12, SSP-13 and SSP-40 demonstrated significant binding to the PPAR-Î³ receptor with good Gold score fitness (73.11, 69.86 and 75.51 respectively) and relative ligand energy (-8.26,-8.33 and-7.82, respectively) as compared to standard drugs i.e. rosiglitazone and pioglitazone, (64.10 and 66.72) and (-4.30 and-2.47) respectively.

Conclusion: The final results of molecular docking along with information gathered from pharmacokinetic parameters of gallic acid derivatives may be utilised further for the development of newer PPAR-Î³ agonists having anti-diabetic potential with better pharmacokinetic and pharmacodynamic profile.

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