• Sushama Pawar Department of Zoology, Bharati Vidyapeeth Deemed University, Yashwantrao Mohite College of Arts, Science and Commerce, Pune 411 038, Maharashtra, India
  • Manmohini Jadhav Department of Zoology, Bharati Vidyapeeth Deemed University, Yashwantrao Mohite College of Arts, Science and Commerce, Pune 411 038, Maharashtra, India




Oxidative stress, Aging, Lipid peroxidation, D-galactose, Bacoside A, Antioxidant


Objective: Bacoside A is a major bioactive constituent of Bacopa monnieri L having antioxidant property. The objective of this study was to evaluate the effect of Bacoside A, on lipid peroxidation in brain, heart and liver during induced aging.

Methods: Male Swiss albino mice, Mus musculus was used for the present investigation. Four experimental groups were used as Group I-Normal adult, Group II-D-galactose induced, Group III-D-galactose induced plus Bacoside A treated and Group IV-Natural aging. The effect of Bacoside A was studied against lipid peroxidation during induced aging. The level of lipid peroxidation in the form of MDA formation was determined and measured in brain, heart and liver.

Results: The statistical data obtained were analyzed using one way ANOVA, control vs other groups and results were expressed as mean±SE. In Bacoside A treated group the lipid peroxidation level in heart, brain and liver was significantly decreased (p<0.001) compared to control group. A significant increase (p<0.0001) in the level of lipid peroxidation was observed in D-galactose induced mice. In natural aging group highly significant increase (p<0.0001) in initial lipid peroxidation, ascorbate dependent lipid peroxidation and spontaneous lipid peroxidation was observed.

Conclusion: The observations revealed that, lipid peroxidation was reversed in Bacoside A treated group which may be due to antioxidant property of Bacoside A. Thus Bacoside A is able to ameliorate the stress induced changes in lipid peroxidation during aging. The findings also provide a theoretical basis for the development of novel therapeutic formulations, such as antioxidant supplementation to boost antioxidant defenses in the body.


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How to Cite

Pawar, S., and M. Jadhav. “EFFECT OF BACOSIDE A ON LIPID PEROXIDATION IN D-GALACTOSE INDUCED AGING MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 9, Sept. 2017, pp. 12-15, doi:10.22159/ijpps.2017v9i9.16874.



Original Article(s)