COMPARATIVE STUDIES OF NOVEL OXADIAZOLE DERIVATIVE HAVING CHIRAL CENTER ANDTHEIRANTI-MICROBIAL ACTIVITIES

Authors

  • Bhavnaben D. Mistry Department of Chemistry, B.K. M. Science College, Valsad 396001, India
  • Kishor R. Desai Department of Chemistry, B.K. M. Science College, Valsad 396001, India
  • Sanket M. Intwala Department of Chemistry, B.K. M. Science College, Valsad 396001, India

Keywords:

1,3,4-Oxadiazol, Spectroscopic study, Antibacterial activity, Antifungal activity

Abstract

Objective: To synthesize a series of (-) S & (+) S oxadiazole derivatives by the reaction of (-) (2S)-2-amino-2-(2-chlorophenyl) acetohydrazide & (+) (2S)-2-amino-2-(2-chloro phenyl) acetohydrazide with con. H2SO4, L(+) Tartaric acid, L(-) Tartaric acid, Hydrazine Hydrate, POCl3 and Various aromatic acid respectively.

Methods: The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data and screened for their antibacterial and antifungal activities against different microorganisms by micro dilution method. Gentamycin, Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Nystatin, Greseofulvin were used as standard drugs for bacterial and fungus.

Results: The newly synthesized compounds indicate that some of them show better antibacterial and antifungal activity than compared to their reference drug.

Conclusion: Comparison of 1, 3, 4 oxadiazole having chiral center, characterized and exhibited promising antibacterial and antifungal activity.

Downloads

Download data is not yet available.

References

Harish KP, Mohana KN. Synthesis of new 2-(2,4-dimethoxyphenyl)-1,3,4-oxadiazoles and their antimicrobial activity, Int. J Bio Sci 2013;4(2):1046-55.

Ahsan MJ, Samy JG, Khalilullah H, Nomani MS, Saraswat P, Gaur R, et al. Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents. Bioorg Med Chem Lett 2011;21(24):7246-50.

Pattan S, Musmade D, Muluk R, Pawar S, Daithankar A, Wabale N, et al. Synthesis, antimicrobial and antitubercular activity of some novel [3-isonicotinoyl 5-(4-substituted)-3-dihydro-1,3,4-oxadiazol-2-yl] and substituted 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-thiol derivatives, Indian J Chem 2013; 52B:293-99.

Anisworth C. 1,3,4-oxadiazole, J. Am. Chem Soc 1965;87(24):5800-1.

Aitken KM, Aitken RA. Improved synthesis and characterization of 1,3,4-oxadiazole, Arkivoc 2012;(v):75-9.

Intwala SM, Mistry BD, Desai KR. Conventional and Microwave induced synthesis of various 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazine derivatives from N-amino-2-{2’-[(2â€,6â€-dichlorophenyl)amino]phenyl}acetamide and their antimicrobial screening, J Indian Council Chem 2010;27(1):89-95.

Bhaskar VH, Francis P, Sangmeswaran B, Jayakar. Synthesis and antimicrobial activity of 3-(5-substituted phenyl-1,3,4-oxadiazol-2-yl)pyridines, Indian J Heter Chem 2006;(15):409-10.

Maslat AO, Abussaud M, Tashtoush H, Al-Talib M. Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives. Pol J Pharmacol 2002;54(1):55-9.

Bakht MA, Islam M, Siddiqui AA. Synthesis and antifungal activity of some new 1,3,4-oxadiazoles. Indian J Heter Chem 2006;(15):297-98.

Jakubkiene V, Burbuliene MM, Mekuskiene G, Udre naite E, Gaidelis P, Vainilavicius P. Synthesis and anti-inflammatory activity of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives, II Farmaco. 2003;58:323-28.

Katritzky AR, Mohapatra PP, Huang L. 1,3,4-oxadiazoles from functionalized n-acylbenzotriazoles and acyl hydrazides, Arkivoc. 2008; (ix):62-68.

Published

01-07-2014

How to Cite

Mistry, B. D., K. R. Desai, and S. M. Intwala. “COMPARATIVE STUDIES OF NOVEL OXADIAZOLE DERIVATIVE HAVING CHIRAL CENTER ANDTHEIRANTI-MICROBIAL ACTIVITIES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 195-8, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1719.

Issue

Section

Original Article(s)