APPLICATION OF 25 FACTORIAL DESIGN IN OPTIMIZATION OF SUPERPOROUS HYDROGEL SYNTHESIS CONTAINING NATURAL MUCILAGE

Authors

  • Pallavi Khanekar Oriental College of Pharmacy, Sector-2, Sanpada, Navi Mumbai, Maharasthra 400705, INDIA
  • Munira Momin Oriental College of Pharmacy, Sector-2, Sanpada, Navi Mumbai, Maharasthra 400705, INDIA
  • Supriya Mhatre Oriental College of Pharmacy, Sector-2, Sanpada, Navi Mumbai, Maharasthra 400705, INDIA

Keywords:

Superporous hydrogel, Fenugreek mucilage, Foam strengtheners, Factorial design

Abstract

Objective: An experimental design, based on 25 factorial designs was used to study the influence of formulation parameters on a swelling and gelling behaviour of synthesized superporous hydrogel. Although a vast variety of formulations parameters could affect the hydrogel networks, attempt was made to synthesize a natural super-disintegrant, i.e., fenugreek mucilage, based super-porous hydrogel.

Methods: A 25 factorial design was adopted to study the effect of various parameters for synthesis of superporous hydrogel using fenugreek mucilage as a foam stabilizer. The gelation features during the synthesis process, including inhibition period, exothermic period were observed. For this study, five formulation variables i.e, type of monomer, amount of cross-linker, redox initiator, redox activator and level of foam strengtheners were chosen and their effects were examined within the frame of a 25 factorial design.

Results: The responses examined were inhibition period, exothermic period and gelling feature along with the physical appearance during gelation and after drying. These responses found to be dependent on the concentration of cross-linker and redox activator (P< 0.05). The resultant hydrogel was subjected to SEM study and it clearly showed that fenugreek mucilage at higher level could stabilise the foam during gelation process which led to better and enhanced porous network formation.

Conclusion: The synthesized superporous hydrogels can be used in for those formulations where fast swelling and superabsorbent properties are critical.

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References

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Published

01-07-2014

How to Cite

Khanekar, P., M. Momin, and S. Mhatre. “APPLICATION OF 25 FACTORIAL DESIGN IN OPTIMIZATION OF SUPERPOROUS HYDROGEL SYNTHESIS CONTAINING NATURAL MUCILAGE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 215-9, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1734.

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