• S. R. K. Neeraja Department of Zoology, SSBN Degree College, Anantapuramu. 515001. A. P, India.
  • P. Giridhar Department of Zoology, Govt Degree College(M), Anantapuramu. 515001. A. P, India.


Deltamethrin, Sublethal, Labeo rohita, Total proteins, Protease activity and Free amino acids


Objective: The contamination of water by pesticides may effect on non - target organisms like fish. So an attempt was made on sublethal effect of deltamethrin on some aspects of protein metabolism in the fish Labeo rohita.

Methods: The fish fingerlings were exposed to sublethal concentration of Deltamethrin for five exposure periods i.e. 1, 7, 15, 20 and 30 day. In this investigation the levels of total proteins, protease activity and free amino acids were estimated in the brain, liver, gill, kidney and muscle of fish.

Results: The levels of total proteins declined on 1st day exposure and continued its declination up to 15th day. From 15th day onwards their levels gradually elevated and came nearer to control on 30th day exposure period. In contrast to this the levels of protease activity and free amino acids followed an opposite tend.

Conclusion: In the present study the shifts in protein metabolism might to compensate with situation shown by the fish for its survival.


Download data is not yet available.


Gold B, Leuschen T, Brunk G, Gingell R. Metabolism of a DDT metabolite via a chlorohepoxide, Chem Bio Interact 1981;35:159.

Pandey AC, Pandey AK and Das P. Fish and fisheries in relation to aquatic pollution In:Environmental Issues and management. S.R. Verma., A.K. Gupta and P. Das 9(Eds) Nature Conservators. Muzaffarnagar 2000;P:87-112.

Glotfelly DE, Majewski MS and Seiber JN. Distribution of several organophosphorus insecticides in a foggy atmosphere. Environ Sci Technol 1990;24:353-57.

Roche H, Tidov A and Persic A. Organochlorine pesticides and biomarker responses in two fishes Oreochromis niloticus (Linnaeus, 1758) and Chrysichthys nigrodigtatus (Lakebed, 1803) and an invertebrate, Macro brachium vollenhoveniil (Herkot, 1857), from the lake Taabo (Cote‘d Ivoire). J Applied Sci 2007;7:3860-69.

Joseph B and Raj SJ. Impact of pesticide toxicity on selected biomarkers in fishes. Int J Zool Res 2011;7:212-22.

Burkpile DE, Moore MT and Holland MT. Susceptibility of five non target organisms to aqueous diazinon exposure. Bull Environ Contam Toxicol 2000;64:114.

Saxena KK and Gupta P. Impact of carbamates on glycogen contents in the muscles of fresh water fish Channa punctatus. Poll Res 2005;24:669-70.

Dutta HM, Misquitta Doyglas and Khan Sanaaullah. The effect of endosulfan on the testis of blue gill fish Lepomis macrochirus. A Histopathological study. Archives. Environ Contam Toxicol 2006;51(1):149-56.

Finney DJ. Probit analysis:2 Edn. Cambridge University Press. London;1964.

Carpentor PL. In:Immunology and Serology. 3rd eds. W.B. Saunders Company. Philadelphia. London. Toronto. P.254;1975.

Lowry OH, Rosenbrough NJ, Farr AL and Randall R. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-75.

Davis NC and Smith EL. Assay of proteolytic enzymes. Meth Biochem Anal 1955;75(20):177-82.

Moore S and Stein WH. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. J Biol Chem 1954;24:907-13.

Jauncey K. Carp(Cyprinus carpio) nutrition a review cited in recent advances in aquaculture, edited J.G. Muir and Roberts, West View Press, INC5500, Colorado1982;PP:222.

Umminger BL. Physiological studies on super cooled kill fish Fundus heteroclitus. III. Carbohydrate metabolism and survival at subzero temperature. J Exp Zool 1970;173:159-74.

Young UR. In:Mammalia protein metabolism(H.N. Mumo. Ed) Academic Press. New York, 1970;4:485.

Ganesan RM, Jebakumar SRD and Jayaraman J. Sublethal effect of organochlorine insecticide endosulfon on protein, carbohydrate and lipid contents in their tissues of Oreochromis mossabicus. Proc Indian Sci (Anim Sci) 1989;98:51-55.

Kamble GB and Muley DV. Effect of acute exposure of endosulfon and chloropyrifos on the biochemical composition of the fish Sarotherondon mossambicus. Indian J Environ Science 2000;4(1):97-102.

Shoba Rani A, Sudharshan R, Reddy TN, Reddy PUM and Raju TN. Effect of Sodium arsenate on certain aspects of protein metabolism in freshwater teleost fish, Tilapia mossambica. J Env Biol 2001;22(2):101-04.

Bhavan SP and Geraldine P. Carbaryl induced alterations in biochemical metabolism of the prawn M. molcolmsonii. Journ Env Biol 2002;23(2):157-62.

John Sushma N, Sivaiah U and Jayantha Rao K. Impact of aluminium acetate on protein metabolism of albino mice. J Ecobiol 2007;20(4):361-67.

Mahananda MR, Sahoo S and Mohanty BP. Effect of insecticide malathion on muscle protein and brain acetylcholinesterase activity in Labeo rohita. J Ecotoxicol Environ Monit 2008;18(1):77-84.

Vijay kumar M, Butchiram MS and Tilak KS. Effect of quinolphos an organophosphorus pesticide on nucleic acids and proteins of the fresh water fish Channa Punctatus. J Ecotoxicol Environ Monit 2009;19(1):07-12.

Visvanathan P, Maruthannayagam C and Govinda Raju M. Effect of malathion and endosulfan on biochemical changes in Channa punctatus. J Ecotoxicol Environ Monit 2009;19(3):251-57.

Abdul Naveed, Janaiah C and Venkateshwarlu P. The effects of lihocin toxicity on protein metabolism of the fresh water edible fish, Channa punctatus (Bloch). Journal of Toxicology and Environmental Health Sciences 2010;Vol. 3(1) pp. 018-023.

Sreenivasa V and Indirani R. Impact of dimethoate on biochemical constituents in the fish Oreochromis mossambicus. J Ecotoxicol Environ Monit 2010;20(2):151-56.

Sindhe SCS, Jagadeesh Naik M, and Indira P. Effect of fungicide ziram on some aspects of protein metabolism in the fresh water teleost Labeo rohita. J Ecotoxicol Environ Monit 2010;20(3):257-61.

Janardhan Reddy S, Loknatha O, Kiran Reddy T and Reddy DC. Effect of heavy metals on physiological parameters of the Indian major carp Catla catla. J Ecotoxicol Envrot Monit 2011;21(5):453-63.

Nagaraj G, Sarma ALN. Survival and biochemical contents of Catla catla exposed to mercuric chloride and their ecological implications. J Ecobiol 2011;28(4):307-20.

Rekha P, John J. Study on the changes in the levels of protein metabolism in λ cyhalothrininduced hepatotoxicity in fresh water Tilapia (Oreochromis Mossambicus). Advances in Applied Science Research 2011;2 (3):57-62.

Lesley Sounderraj SF, Sekhar P, Senthil Kumar P and Nancy Lesley. Effect of Systemic Pesticide Phosphamidon on Haematological Aspects of Common Frog Rana tigrina. Int J Pharma Biol Archi 2011;2(6):1776-1780.

Seshagiri RK, Srinivas M, Kashi Reddy B, Swamy KS, Chetty CS. Effect of benthiocarb on protein metabolism of teleost, Sarotherodon mossambicus. Ind J Environ Health 1987;29:440-450.

Bhavan PS, Geraldine P. Manifestation of carbaryl toxicity on soluble protein and histopathology in the hepatopancreas and gills of the prawn, Macrobrachium malcolmsonii. J Environ Biol 2009;30(4):533-538.

Magar RS, Afsar Shaikh. Biochemical changes in proteins and amino acids in Channa punctatus in responses to sublethal treatment with the insecticide malathion. Trends in Life Sciences 2012;Vol:1, No:3

Pratap B and Singh A. In vivo Effects of Apigenin isolated from Jatropha gossypifolia plant on the Biochemical Profile of Fish. Global Journal of Pharmacology 2013;7 (2):166-171.

Ram Yadav P and Ajay Singh. Toxic effects of Selected Plant Pesticides against Freshwater Snail Lymnaea acuminate. Int J Trad Nat Med 2013;2(3):149-163.

Singh SP and Singh S. Metabolic effects of an organophosphorus dipterex in Trichogaster fasciatus. Ind J Biol Res 2011;Vol:1(1):P 61-66.

Fahmy GH. Malathion toxicity:Effect of some metabolic activities in Oreochromis niloticus, the Tilapia fish. Int J Bio Biochem and Bioinf 2012;2(1):52-55.

Arun Kumar MS and Jawahar Ali A. Toxic impact of two organophosphorus pesticides on acetylcholinesterase activity and biochemical composition of fresh water fairy shrimp Streptocephalus dichotomous. Int J Pharma Biosci 2013;(4)2:(B/P):966-972.

Vidhya V, Nair CR. Lambda-Cyhalothrin Induced Protein Alternations in Etroplus suratensis (Bloch). Global Journal of Pharmacology 2013;7 (2):166-171.

Binukumari S, Vasanthi J. The Toxic Effect of Pesticide Dimethoate 30% EC on the protein metabolism of the fresh water fish, Labeo rohita. Int J Curr Microbiol App Sci 2013;(2013) 2(12):79-82.

Nagarju B and Venkata Ratnamma V. Effect of profenos an organophosphate on protein levels in some tissues of fresh water fish Labeo rohita (Hamilton). Int J Pharma Pharma Sci 2013;Vol:5, Suppl:1, 276-79.

Shivanagouda N, Sanagoudra U, Bhat G. Carbaryl Induced Changes in the Protein and Cholesterol Contents in the Liver and Muscle of Marine Benthic Fish, Mugil cephalus. American Journal of Biochemistry 2013;3(2):29-33.

Suneel K. Acute toxicity evaluation of nuvan in liver of Channa punctatus (Bloch). Adv Res Agri Vet Sci 2014;Vol:1,No:3, 35-38

Pratiba R, Varsha Z, Dinesh D, Neeta L. Evaluation of impact of phosphamidon on protein status of fresh water fish Channa punctatus. Indian Journal Sci Res 2012;3(1):123-26.

Dixon DG, Sprague JB. Copper bioaccumulation and hepato protein synthesis during acclimation to copper by juvenile rainbow trout. Aquatic Toxicol 1981;1:69-81.

Kito H, Osc Y, Sato T and Ishikawa T. Formation of metalloprotein in fish. Comp Biochem Physiol 1982;73C (1):129-34.

Pampatwar DV, Ambore NE and Kadam MS. Effect of activity level on total amino acid content in liver of Channa gaucha and Labeo rohita a comparative study. J Aqua Boil 2007;22(1):125-27.



How to Cite

Neeraja, S. R. K., and P. Giridhar. “EFFECT OF DELTAMEFFECT OF DELTAMETHRIN ON SOME ASPECTS OF PROTEIN METABOLISM IN FRESH WATER FISH LABEO ROHITA (HAMILTON)ETHRIN ON SOME ASPECTS OF PROTEIN METABOLISM IN FRESH WATER FISH LABEO ROHITA (HAMILTON)”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 494-7, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1746.



Original Article(s)