DEVELOPEMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF CILNIDIPINE AND OLMESARTAN MEDOXOMIL IN BULK AND TABLET DOSAGE FORM BY RP-HPLC

Authors

  • Amit S. Minase Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune-411048, Maharashtra, India
  • Manjusha N. Dole Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune-411048, Maharashtra, India
  • Sanjay D. Sawant Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune-411048, Maharashtra, India

Keywords:

Cilnidipine, Olmesartan Medoxomil, RP-HPLC

Abstract

An economical, precise, rapid and accurate RP HPLC method has been developed for the simultaneous estimation of Olmesartan Medoxomil and Cilnidipine in bulk and tablet dosage form. Separation was carried out on Jasco HPLC system equipped with HiQ sil C18 column (250 × 4.6 mm i.d.) and PDA detector using Methanol: 40 mM Potassium dihydrogen ortho phosphate buffer (90:10 v/v) as the mobile phase.Ortho-phosphoric acid was used to adjust pH to 3.0, and detection was carried out at 254 nm. Results were linear in the range of 5-30 μg/ml for Cilnidipine and 10-50 μg/ml for Olmesartan Medoxomil respectively. The method was successfully applied for the analysis of drugs in pharmaceutical formulation. Results of the analysis were validated statistically and by recovery studies.

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References

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Published

01-07-2014

How to Cite

Minase, A. S., M. N. Dole, and S. D. Sawant. “DEVELOPEMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF CILNIDIPINE AND OLMESARTAN MEDOXOMIL IN BULK AND TABLET DOSAGE FORM BY RP-HPLC”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 508-11, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1750.

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