PHYTOCHEMICAL SCREENING AND ANALGESIC EFFECTS OF ETHANOLIC EXTRACT OF PLANT MURDANIA NUDIFLORA (L) BRENAN (COMMELINACEAE) IN ALBINO MICE USING HOT PLATE METHOD

Authors

  • Bhargab Nath Patwari Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati 781017, Assam
  • Abdul Baqee Ahmed Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati 781017, Assam
  • Trishna Das Girijananda Chowdhury Institute of Pharmaceutical Science, Hathkhowapara, Azara, Guwahati 781017, Assam
  • Rupa Sengupta ROFEL, Shri G.M.Bilakhia College of Pharmacy, Namdha Road, Vapi 396191 Gujarat, India

Keywords:

Murdania nudiflora (L) Brenan(Commelinaceae), Morphine sulphate, Plate reaction time, pain and inflammatory conditions

Abstract

Objective: Murdania nudiflora (L) Brenan (Commelinaceae) has long been used in folk medicine in treatment of many diseases. In this study, attempts have been made for pharmacological screening of the plant Murdania nudiflora (L) Brenan (Commelinaceae) for analgesic activity and presence of different phytochemicals.

Methods: To this end, ethanolic extract of Murdania nudiflora (L) Brenan (Commelinaceae) was evaluated for analgesic properties using plate reaction time in mice and phytochemical screening of the plant was done by different methods.

Results: The analgesic study showed that the ethanolic extract of the leaves have significant analgesic effects (P < 0.05; P < 0.001) as compared to morphine sulphate (10 mg/kg) used as a standard drug. The result of the preliminary phytochemical studies revealed the presence of tannins, flavonoids, saponins, alkaloids as a whole and which are reported to be responsible for the analgesic and anti-inflammatory activities in many medicinal plants of this family.

Conclusion: From these studies, it may be concluded that ethanol extracts of Murdania nudiflora (L) Brenan may contain novel bioactive principles with analgesic activity. Further study is required for evaluation of active principle(s) in different animal models.

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Published

01-07-2014

How to Cite

Patwari, B. N., A. B. Ahmed, T. Das, and R. Sengupta. “PHYTOCHEMICAL SCREENING AND ANALGESIC EFFECTS OF ETHANOLIC EXTRACT OF PLANT MURDANIA NUDIFLORA (L) BRENAN (COMMELINACEAE) IN ALBINO MICE USING HOT PLATE METHOD”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 512-5, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1751.

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