STUDY OF CAMELLIA SINENSIS AND BOSWELLIA SERRATA IN RESPECT TO ANTIANGIOGENIC EFFECT

Authors

  • Page Amit B. Department of Pharmacology, School of Pharmacy and Technology Management, NMIMS, Shirpur (M.S.), India
  • Kulkarni Kala S. Department of Pharmacology, School of Pharmacy and Technology Management, NMIMS, Shirpur (M.S.), India

Keywords:

Boswellia serrata, Camellia sinensis, Safety, Angiogenesis, CAM, Angiogenesis dependent disease, Arthritis, Metastasis

Abstract

Objective: The process of angiogenesis is finely balanced by Proangiogenic factors and antiangiogenic factors. Any imbalance between these factors may result in a group of diseases with varied morphologic and pathologic changes, called angiogenesis dependent diseases. One has to arrest the growth of unwanted blood vessels like in metastasis of tumour, arthritis, retinopathies, etc. As the angiogenesis is simultaneously controlled by several factors, one needs to target the whole process through a holistic approach i.e. targeting more than one mechanism at a time. Objective of our study was to evaluate antiangiogenic potentials of Camellia sinensis and Boswellia serrata in whole animal models along with their safety individually as well as in combination.

Methods: These extracts were evaluated for their antiangiogenic effect using three models – Chicken Chorioallentoic membrane assay, Rat Subcutaneous air sac and Mesenteric window angiogenesis.

Results: The results of toxicity study showed that aqueous extracts of Camellia sinensis and Boswellia serrata are safe on oral administration in acute as well as repeated dose toxicity studies. It also showed antiangiogenic effects of individual extracts as well as their combinations. The study suggests that there may be synergistic effect in these extracts particularly in mesenteric window model.

Conclusion: From the study it can be concluded that these extracts can be clinically evaluated on angiogenesis dependent diseases.

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Published

01-07-2014

How to Cite

B., P. A., and K. K. S. “STUDY OF CAMELLIA SINENSIS AND BOSWELLIA SERRATA IN RESPECT TO ANTIANGIOGENIC EFFECT”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 542-6, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/1757.

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